Structure of PDB 6rey Chain d

Receptor sequence
>6reyd (length=1773) Species: 9606 (Homo sapiens) [Search protein sequence]
FVPQKEIVYNKLLPYAERLDAESDLQLAQIKCNLGRAVQLQELWPGGLFW
TRKLSTYIRLYGRKFSKEDHVLFIKLLYELVSIPKLEISMMQGFARLLIN
LLKKKELLSRADLELPWRPLYDMVERILYSKTEHLGLNWFPNSVENILKT
LVKSCRPYFPADATAEMLEEWRPLMCPFDVTMQKAITYFEIFLPTSLPPE
LHHKGFKLWFDELIGLWVSVQNLPQWEGQLVNLFARLATDNIGYIDWDPY
VPKIFTRILRSLNLPVGSSQVLVPRFLTNAYDIGHAVIWITAMMGGPSKL
VQKHLAGLFNSITSFYHPSNNGRWLNKLMKLLQRLPNSVVRRLHRERYKK
PSWLTPVPDSHKLTDQDVTDFVQCIIQPVLLAMFSKTGSLEAAQALQNLA
LMRPELVIPPVLERTYPALETLTEPHQLTATLSCVIGVARSLVSGGRWFP
EGPTHMLPLLMRALPGVDPNDFSKCMITFQFIATFSTLVPLVDCSSVLQE
RNDLTEVERELCSATAEFEDFVLQFMDRCFGLIESSTLEQTREETETEKM
THLESLVELGLSSTFSTILTQCSKEIFMVALQKVFNFSTSHIFETRVAGR
MVADMCRAAVKCCPEESLKLFVPHCCSVITQLTMNDDVLNDEELDKELLW
NLQLLSEITRVDGRKLLLYREQLVKILQRTLHLTCKQGYTLSCNLLHHLL
RSTTLIYPTEYCSVPGGFDKPPSEYFPIKDWGKPGDLWNLGIQWHVPSSE
EVSFAFYLLDSFLQPELVKLQHCGDGKLEMSRDDILQSLTIVHNCLIGSG
NLLPPLKGEPVTNLVPSMVSLEETKLYTGLEYDLSRENHREVIATVIRKL
LNHILDNSEDDTKSLFLIIKIIGDLLQFQGSHKHEFDSRWKSFNLVKKSM
ENRLHGKKQHIRALLIDRVMLQHELRTLTVEGCEYKKIHQDMIRDLLRLS
TSSYSQVRNKAQQTFFAALGAYNFCCRDIIPLVLEFLRPDRQGVTQQQFK
GALYCLLGNHSGVCLANLHDWDCIVQTWPAIVSSGLSQAMSLEKPSIVRL
FDDLAEKIHRQYETIGLDFTIPKSCVEIAELLQQSKNPSINQILLSPEKI
KEGIKRQQEKNADALRNYENLVDTLLDGVEQRNLPWKFEHIGIGLLSLLL
RDDRVLPLRAIRFFVENLNHDAIVVRKMAISAVAGILKQLKRTHKKLTIN
PCEISGCPDRPDNHWLHYDSKTIPRTKKEWESSCFVEKTHWGYYTWPKNM
VVYAGVEEQPKLGRSREDMTEAEQIIFDHFSDPKFVEQLITFLSLEDRKG
KDKFNPRRFCLFKGIFRNFDDAFLPVLKPHLEHLVADSHESTQRCVAEII
AGLIRGSKHWTFEKVEKLWELLCPLLRTALSNITVETYNDWGACIATSCE
SRDPRKLHWLFELLLESPLSGEGGSFVDACRLYVLQGGLAQQEWRVPELL
HRLLKYLEPKLTQVYKNVRERIGSVLTYIFMIDVSLPNTTPTISPHVPEF
TARILEKLKPLMTQGIKLLKTILKWLMASAGRSFSTAVTEQLQLLPLFFK
IAPVENDNSYDELKRDAKLCLSLMSQGLLYPHQVPLVLQVLKQTARSSSW
HARYTVLTYLQTMVFYNLFIFLNNEDAVKDIRWLVISLLEDEQLEVREMA
ATTLSGLLQCNFLTMDSPMQIHFEQLCKTKLPKAELVKRHAGVLGLGACV
LSSPYDVPTWMPQLLMNLSAHLNDPQPIEMTVKKTLSNFRRTHHDNWQEH
KQQFTDDQLLVLTDLLVSPCYYA
3D structure
PDB6rey Characterization of Fully Recombinant Human 20S and 20S-PA200 Proteasome Complexes.
Chaind
Resolution3.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 IHP d K156 K1216 K1271 Y1286 K1346 R1350 R1388 S1434 R1435 K131 K1191 K1238 Y1253 K1313 R1317 R1355 S1401 R1402
BS02 K0W d Y34 K129 W915 K932 R943 Y9 K104 W890 K907 R918
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0016504 peptidase activator activity
GO:0070577 lysine-acetylated histone binding
GO:0070628 proteasome binding
Biological Process
GO:0006281 DNA repair
GO:0006974 DNA damage response
GO:0007283 spermatogenesis
GO:0010499 proteasomal ubiquitin-independent protein catabolic process
GO:0030154 cell differentiation
GO:0035092 sperm DNA condensation
Cellular Component
GO:0000502 proteasome complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016607 nuclear speck
GO:1990111 spermatoproteasome complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6rey, PDBe:6rey, PDBj:6rey
PDBsum6rey
PubMed31473102
UniProtQ14997|PSME4_HUMAN Proteasome activator complex subunit 4 (Gene Name=PSME4)

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