Structure of PDB 6fqm Chain d

Receptor sequence
>6fqmd (length=150) Species: 158879 (Staphylococcus aureus subsp. aureus N315) [Search protein sequence]
ADCSKSPEECEIFLVEGDSDSRTQAILPLRGKILNVEKARLDRILNNNEI
RQMITAFGTGIGGDFDLAKARYHKIVIMTDADVDGAHIRTLLLTFFYRFM
RPLIEAGYVYIAQLLQVKLEDAIEADQTFEMLMGDVVENRRQFIEDNAVY
3D structure
PDB6fqm A new class of antibacterials, the imidazopyrazinones, reveal structural transitions involved in DNA gyrase poisoning and mechanisms of resistance.
Chaind
Resolution3.06 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 5.6.2.2: DNA topoisomerase (ATP-hydrolyzing).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna d E435 G459 K460 D512 E16 G31 K32 D84
BS02 dna d K460 L462 N463 K466 N475 H515 V626 R629 K32 L34 N35 K38 N47 H87 V137 R140
BS03 MN d D508 D510 D80 D82
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005524 ATP binding
Biological Process
GO:0006265 DNA topological change

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Molecular Function
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Biological Process
External links
PDB RCSB:6fqm, PDBe:6fqm, PDBj:6fqm
PDBsum6fqm
PubMed29538767
UniProtP66937|GYRB_STAAN DNA gyrase subunit B (Gene Name=gyrB)

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