Structure of PDB 5mu8 Chain d

Receptor sequence
>5mu8d (length=138) Species: 9606 (Homo sapiens) [Search protein sequence]
SDKPVAHVVANPQAEGQLQWLLLANGVELRDNQLVVPSEGLYLIYSQVLF
KGQGCPSTHVLLTHTISRIAVSYQTKVNLLSAIKSPCQRETPKPWYEPIY
LGGVFQLEKGDRLSAEINRPDYLDFAESGQVYFGIIAL
3D structure
PDB5mu8 Structural Basis of Small-Molecule Aggregate Induced Inhibition of a Protein-Protein Interaction.
Chaind
Resolution3.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 JNI d L57 Y119 Y151 L43 Y100 Y132 BindingDB: IC50=1200nM
BS02 JNI d S9 D10 V13 I155 S1 D2 V5 I136 BindingDB: IC50=1200nM
Gene Ontology
Molecular Function
GO:0005164 tumor necrosis factor receptor binding
Biological Process
GO:0006955 immune response
Cellular Component
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:5mu8, PDBe:5mu8, PDBj:5mu8
PDBsum5mu8
PubMed28300404
UniProtP01375|TNFA_HUMAN Tumor necrosis factor (Gene Name=TNF)

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