Structure of PDB 7a01 Chain c3

Receptor sequence

>7a01c3 (length=206) Species: 9986 (Oryctolagus cuniculus)

GISRDNWHKRRKTGGKRKPYHKKRKYELGRPAANTKIGPRRIHTVRVRGG
NKKYRALRLDVGNFSWGSECCTRKTRIIDVVYNASNNELVRTKTLVKNCI
VLIDSTPYRQWYESHYALPLGRKKGAKLTPEEEEILNKKRSKKIQKKYDE
RKKNAKISSLLEEQFQQGKLLACIASRPGQCGRADGYVLEGKELEFYLRK
IKARKG

3D structure

• PDB: 7a01 The Halastavi arva Virus Intergenic Region IRES Promotes Translation by the Simplest Possible Initiation Mechanism.
• Chain: c3
• Resolution: 3.6 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	c3	E89 Q167 Q168	E88 Q166 Q167
BS02	rna	c3	G2 R5 D6 N7 H9 K10 R11 R12 T14 R18 K19 P20 Y21 H22 K23 K24 R25 K26 Y27 L29 R31 R41 I43 T45 R47 V48 R49 G50 G51 K54 Y55 R56 R59 N64 S66 C71 C72 T73 R74 K75 A85 S86 V97 K98 W112 H116 Y117 K140 R141 K143 K144 K147 Y149 R178 G180 Q181 G183 R184 D186 G187 Y188	G1 R4 D5 N6 H8 K9 R10 R11 T13 R17 K18 P19 Y20 H21 K22 K23 R24 K25 Y26 L28 R30 R40 I42 T44 R46 V47 R48 G49 G50 K53 Y54 R55 R58 N63 S65 C70 C71 T72 R73 K74 A84 S85 V96 K97 W111 H115 Y116 K139 R140 K142 K143 K146 Y148 R177 G179 Q180 G182 R183 D185 G186 Y187

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
• GO:0006412 translation

Cellular Component

• GO:0005634 nucleus
• GO:0005730 nucleolus
• GO:0005737 cytoplasm
• GO:0005840 ribosome
• GO:0016020 membrane
• GO:0022626 cytosolic ribosome
• GO:0022627 cytosolic small ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:7a01, PDBe:7a01, PDBj:7a01
• PDBsum: 7a01
• PubMed: 33296660
• UniProt: G1TJW1|RS8_RABIT Small ribosomal subunit protein eS8 (Gene Name=RPS8)