Structure of PDB 8tym Chain c

Receptor sequence
>8tymc (length=699) Species: 9606 (Homo sapiens) [Search protein sequence]
MGNRGMEDLIPLVNRLQDAFSAIGQNADLDLPQIAVVGGQSAGASSVLEN
FVGRDFLPRGSGIVTRRPLVLQLVNATTEYAEFLHCKGKKFTDFEEVRLE
IEAETDRVTGTNKGISPVPINLRVYSPHVLNLTLVDLPGMTKVPVGDQPP
DIEFQIRDMLMQFVTKENCLILAVSPANSDLANSDALKVAKEVDPQGQRT
IGVITKLDLMDEGTDARDVLENKLLPLRRGYIGVVNRSQKDIDGKKDITA
ALAAERKFFLSHPSYRHLADRMGTPYLQKVLNQQLTNHIRDTLPGLRNKL
QSQLLSIEKEVEEYKNFRPDDPARKTKALLQMVQQFAVDFEKRIEGSGDQ
IDTYELSGGARINRIFHERFPFELVKMEFDEKELRREISYAIKNIHGIRT
GLFTPDMAFETIVKKQVKKIREPCLKCVDMVISELISTVRQCTKKLQQYP
RLREEMERIVTTHIREREGRTKEQVMLLIDIELAYMNTNHEDFIGFIRKG
WLTINNIGIMKGGSKEYWFVLTAENLSWYKDDEEKEKKYMLSVDNLKLRD
VEKGFMSSKHIFALFNTEQRNVYKDYRQLELACETQEEVDSWKASFLRAG
VYPEPQLERQVETIRNLVDSYMAIVNKTVRDLMPKTIMHLMINNTKEFIF
SELLANLYSCGDQNTLMEESAEQAQRRDEMLRMYHALKEALSIIGNINT
3D structure
PDB8tym Cryo-EM structures of membrane-bound dynamin in a post-hydrolysis state primed for membrane fission.
Chainc
Resolution3.58 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.5: dynamin GTPase.
Interaction with ligand
Site
#
Ligand Ligand
chain
Binding residues on receptor
(original residue number in PDB)
Binding residues on receptor
(residue number reindexed from 1)
Binding affinity
BS01 GDP c S41 A42 G43 A44 S45 R59 G60 K206 D208 N236 R237 S238 Q239 S41 A42 G43 A44 S45 R59 G60 K206 D208 N236 R237 S238 Q239
BS02 MG c S45 T65 S45 T65
External links
PDB RCSB:8tym, PDBe:8tym, PDBj:8tym
PDBsum8tym
PubMed38663399
UniProtQ05193|DYN1_HUMAN Dynamin-1 (Gene Name=DNM1)

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