Structure of PDB 8om2 Chain c

Receptor sequence

>8om2c (length=483) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]

KELRLLSKTLQGQSYRDQLELNPDVSKAINNNIMAVHIPNNLRRVATNYY
KEIQEPNSLHRPCRTKMEVDAHIASIFLQNYGSIFQSLKELQKRVGPDNF
KPQRILDVGYGPATGIVALNDILGPNYRPDLKDAVILGNAEMQERAKIIL
SRQLNEVVDTTKKINIMTNLRSSIPASKEYDLIILTHQLLHDGNQFPIQV
DENIEHYLNILAPGGHIVIIERGNPMGFEIIARARQITLRPENFPDEFGK
IPRPWSRGSSNYFLKVIAPCPHQRKCPLQVGNPNFYTHKEGKDLKFCNFQ
KSIKRPKFSIELKKGKLLATSWDRNGRDYEILNYSYLIFERSHKDENTLK
EIKKLRNENVNGKYDIGSLGDDTQNSWPRIINDPVKRKGHVMMDLCAPSG
ELEKWTVSRSFSKQIYHDARKSKKGDLWASAAKTQIKGLGDLNVKKFHKL
EKERIKQLKKEERQKARKAMESYNELEDSLQFD

3D structure

PDB

8om2 METTL17 is an Fe-S cluster checkpoint for mitochondrial translation.

Chain

Resolution

2.57 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.1.1.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	c	Y109 I112 Q113 I135 Q138 I287 G312 N313 P314 H391 K392 K398 F399 Q403 R408 K416 K419 L421 A422 T423 S424 W425 R441 N442 G443 R444 Y446 I448 N450 I498 N499 R504 K505 H507 M509 D511 K521 R526 S527 R537 E570 L575 K576 E579 R580 Q581 R584 K585	Y50 I53 Q54 I76 Q79 I198 G223 N224 P225 H288 K289 K295 F296 Q300 R305 K313 K316 L318 A319 T320 S321 W322 R324 N325 G326 R327 Y329 I331 N333 I381 N382 R387 K388 H390 M392 D394 K404 R409 S410 R420 E453 L458 K459 E462 R463 Q464 R467 K468
BS02	SF4	c	P372 C373 H375 C379 P380 C400 C513	P269 C270 H272 C276 P277 C297 C396

Gene Ontology

	Molecular Function
GO:0003735	structural constituent of ribosome
GO:0008168	methyltransferase activity
GO:0046872	metal ion binding
GO:0051536	iron-sulfur cluster binding
GO:0051539	4 iron, 4 sulfur cluster binding

	Biological Process
GO:0006412	translation
GO:0032543	mitochondrial translation
GO:0180026	mitochondrial small ribosomal subunit assembly

	Cellular Component
GO:0005739	mitochondrion
GO:0005763	mitochondrial small ribosomal subunit

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component

External links

PDB	RCSB:8om2, PDBe:8om2, PDBj:8om2
PDBsum	8om2
PubMed	38199006
UniProt	P36056\|RT22_YEAST Ribosome assembly protein RSM22, mitochondrial (Gene Name=RSM22)

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