Structure of PDB 8gxs Chain c

Receptor sequence
>8gxsc (length=263) Species: 9606 (Homo sapiens) [Search protein sequence]
VSVNLEAFSQAISAIQALRSSVSRVFDCLKDGMRNKETLEGREKAFIAHF
QDNLHSVNRDLNELERLSNLVLYSQLLQAYKWSNKLQYHAGLASGLLNQQ
SLKRSANQLVLPPQYVDDVISRIDRMFPEMSIHLSRPNGTSAMLLVTLGK
VLKVIVVMRSLFIDRTIVKGYNENVYTEDLDIWSKSNYQVFQKVTDHATT
ALLHYQLPQMPDVVVRSFMTWLRSYIKLFQAPCQRCGKFLQDGLPPTWRD
FRTLEAFHDTCRQ
3D structure
PDB8gxs Structures of +1 nucleosome-bound PIC-Mediator complex.
Chainc
Resolution4.16 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN c C281 H306 C309 C233 H258 C261
Gene Ontology
Molecular Function
GO:0003713 transcription coactivator activity
GO:0005515 protein binding
GO:0061630 ubiquitin protein ligase activity
Biological Process
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006367 transcription initiation at RNA polymerase II promoter
GO:0016567 protein ubiquitination
GO:0032968 positive regulation of transcription elongation by RNA polymerase II
GO:0035019 somatic stem cell population maintenance
GO:0051123 RNA polymerase II preinitiation complex assembly
GO:0060261 positive regulation of transcription initiation by RNA polymerase II
Cellular Component
GO:0000151 ubiquitin ligase complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription regulator complex
GO:0005730 nucleolus
GO:0005829 cytosol
GO:0016592 mediator complex
GO:0070847 core mediator complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8gxs, PDBe:8gxs, PDBj:8gxs
PDBsum8gxs
PubMed36201575
UniProtQ6P2C8|MED27_HUMAN Mediator of RNA polymerase II transcription subunit 27 (Gene Name=MED27)

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