Structure of PDB 8a98 Chain c

Receptor sequence

>8a98c (length=227) Species: 347515 (Leishmania major strain Friedlin)

AAFKQQQTESFKKAVVARKAAKAALKKTAYLRARKYSREYRGAEKKLVTL
RRQAASHGNYYLEAKPKVAVVTRIRGIAKVNPKQRKILQLLRLRQIFNTV
FVKMNKPMENMLRAVEPYIAYGYPSLATVRAMVYKRGYLKINGQRVKITD
NQMIKDKYNNVDIVCAEDMVNQIYTCGKHFRTVTHGMWPFKLAPPAGGMR
QKRRHFVEGGDYGNRDTLINRFLARMI

3D structure

• PDB: 8a98 CRYO-EM STRUCTURE OF LEISHMANIA MAJOR 80S RIBOSOME : snoRNA MUTANT
• Chain: c
• Resolution: 2.46 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	c	S35 Y55 R59 R63 G67 K70 R77 H82 R100 G101 I102 K104 N106 P107 K108 K111 I112 L115 R117 Q120 N130 P132 N135 S150 R161 Q169 R170 R206 H210 K216 L217 P219 A221 G222 G223 M224 K227 T242 N245 R246 A249 R250	S10 Y30 R34 R38 G42 K45 R52 H57 R75 G76 I77 K79 N81 P82 K83 K86 I87 L90 R92 Q95 N105 P107 N110 S125 R136 Q144 R145 R181 H185 K191 L192 P194 A196 G197 G198 M199 K202 T217 N220 R221 A224 R225
BS02	rna	c	E141 R228 H230	E116 R203 H205

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

Cellular Component

• GO:0005737 cytoplasm
• GO:0005840 ribosome
• GO:0022625 cytosolic large ribosomal subunit

External links

• PDB: RCSB:8a98, PDBe:8a98, PDBj:8a98
• PDBsum: 8a98
• PubMed: 38722744
• UniProt: Q4Q9H4