Structure of PDB 7naq Chain c

Receptor sequence
>7naqc (length=1799) Species: 9606 (Homo sapiens) [Search protein sequence]
RGFVPQKEIVYNKLLPYAERLDAESDLQLAQIKCNLGRAVQLQELWPGGL
FWTRKLSTYIRLYGRKFSKEDHVLFIKLLYELVSIPKLEISMMQGFARLL
INLLKKKELLSRADLELPWRPLYDMVERILYSKTEHLGLNWFPNSVENIL
KTLVKSCRPYFPADATAEMLEEWRPLMCPFDVTMQKAITYFEIFLPTSLP
PELHHKGFKLWFDELIGLWVSVQNLPQWEGQLVNLFARLATDNIGYIDWD
PYVPKIFTRILRSLNLPVGSSQVLVPRFLTNAYDIGHAVIWITAMMGGPS
KLVQKHLAGLFNSITSFYHPSNNGRWLNKLMKLLQRLPNSVVRRLHRERY
KKPSWLTPVPDSHKLTDQDVTDFVQCIIQPVLLAMFSKTGSLEAAQALQN
LALMRPELVIPPVLERTYPALETLTEPHQLTATLSCVIGVARSLVSGGRW
FPEGPTHMLPLLMRALPGVDPNDFSKCMITFQFIATFSTLVPLVDCSSVL
QERNDLTEVERELCSATAEFEDFVLQFMDRCFGLIESSTLEQTREETETE
KMTHLESLVELGLSSTFSTILTQCSKEIFMVALQKVFNFSTSHIFETRVA
GRMVADMCRAAVKCCPEESLKLFVPHCCSVITQLTMNDDVLNDEELDKEL
LWNLQLLSEITRVDGRKLLLYREQLVKILQRTLHLTCKQGYTLSCNLLHH
LLRSTTLIYPTEYCSVPGGFDKPPSEYFPIKDWGKPGDLWNLGIQWHVPS
SEEVSFAFYLLDSFLQPELVKLQHCGDGKLEMSRDDILQSLTIVHNCILG
SGNLLPPLKGEPVTNLVPSMVSLEETKLYTGLEYDLSRENHREVIATVIR
KLLNHILDNSEDDTKSLFLIIKIIGDLLQFQGSHKHEFDSRWKSFNLVKK
SMENRLHGKKQHIRALLIDRVMLQHELRTLTVEGCEYKKIHQDMIRDLLR
LSTSSYSQVRNKAQQTFFAALGAYNFCCRDIIPLVLEFLRPDRQGVTQQQ
FKGALYCLLGNHSGVCLANLHDWDCIVQTWPAIVSSGLSQAMSLEKPSIV
RLFDDLAEKIHRQYETIGLDFTIPKSCVEIAELLQQSKNPSINQILLSPE
KIKEGIKRQQEKNADALRNYENLVDTLLDGVEQRNLPWKFEHIGIGLLSL
LLRDDRVLPLRAIRFFVENLNHDAIVVRKMAISAVAGILKQLKRTHKKLT
INPCEISGCPKPTQIIAGDRPDNHWLHYDSKTIPRTKKEWESSCFVEKTH
WGYYTWPKNMVVYAGVEEQPKLGRSREDMTEAEQIIFDHFSDPKFVEQLI
TFLSLEDRKGKDKFNPRRFCLFKGIFRNFDDAFLPVLKPHLEHLVADSHE
STQRCVAEIIAGLIRGSKHWTFEKVEKLWELLCPLLRTALSNITVETYND
WGACIATSCESRDPRKLHWLFELLLESPLSGEGGSFVDACRLYVLQGGLA
QQEWRVPELLHRLLKYLEPKLTQVYKNVRERIGSVLTYIFMIDVSLPNTT
PTISPHVPEFTARILEKLKPLMEEDERTQGIKLLKTILKWLMASAGRSFS
TAVTEQLQLLPLFFKIAPVENDNSYDELKRDAKLCLSLMSQGLLYPHQVP
LVLQVLKQTARSSSWHARYTVLTYLQTMVFYNLFIFLNNEDAVKDIRWLV
ISLLEDEQLEVREMAATTLSGLLQCNFLTMDSPMQIHFEQLCKTKLPKKR
KRDPDTIPSAELVKRHAGVLGLGACVLSSPYDVPTWMPQLLMNLSAHLND
PQPIEMTVKKTLSNFRRTHHDNWQEHKQQFTDDQLLVLTDLLVSPCYYA
3D structure
PDB7naq Structural insights into the human PA28-20S proteasome enabled by efficient tagging and purification of endogenous proteins.
Chainc
Resolution3.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 IHP c K156 K1213 K1216 H1219 K1271 Y1286 K1346 R1388 K1391 R1435 K133 K1190 K1193 H1196 K1248 Y1263 K1323 R1365 K1368 R1412
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0016504 peptidase activator activity
GO:0070577 lysine-acetylated histone binding
GO:0070628 proteasome binding
Biological Process
GO:0006281 DNA repair
GO:0006974 DNA damage response
GO:0007283 spermatogenesis
GO:0010499 proteasomal ubiquitin-independent protein catabolic process
GO:0030154 cell differentiation
GO:0035092 sperm DNA condensation
Cellular Component
GO:0000502 proteasome complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016607 nuclear speck
GO:1990111 spermatoproteasome complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7naq, PDBe:7naq, PDBj:7naq
PDBsum7naq
PubMed35858375
UniProtQ14997|PSME4_HUMAN Proteasome activator complex subunit 4 (Gene Name=PSME4)

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