Structure of PDB 6yu1 Chain c

Receptor sequence
>6yu1c (length=350) Species: 9606 (Homo sapiens) [Search protein sequence]
SMQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECL
DHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSD
WFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFL
HENQLTHTDLKPENILFVNSEFETLEEKSVKNTSIRVADFGSATFDHEHH
TTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENRE
HLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPL
KSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERS
3D structure
PDB6yu1 DFG-1 Residue Controls Inhibitor Binding Mode and Affinity, Providing a Basis for Rational Design of Kinase Inhibitor Selectivity.
Chainc
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.12.1: dual-specificity kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 KHC c L162 K186 F236 L238 L239 G240 K241 N242 L290 L38 K62 F112 L114 L115 G116 K117 N118 L166
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:6yu1, PDBe:6yu1, PDBj:6yu1
PDBsum6yu1
PubMed32787076
UniProtP49761|CLK3_HUMAN Dual specificity protein kinase CLK3 (Gene Name=CLK3)

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