Structure of PDB 5umd Chain c

Receptor sequence

>5umdc (length=89) Species: 36329 (Plasmodium falciparum 3D7) [Search protein sequence]

GKAGKGTGSFGKRNGKTHFLCLRCGKRSYHLQKKKCASCGYPSAKKRRFN
WSVKAKRRNTTGTGRCRYIKTLRRKLKNKFTEGSTPKPK

3D structure

PDB

5umd Mefloquine targets the Plasmodium falciparum 80S ribosome to inhibit protein synthesis.

Chain

Resolution

3.2 Å

3D
structure

Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	rna	c	G2 K3 K6 G7 T8 S10 F11 G12 K13 R14 N15 G16 K17 T18 H19 K27 R28 H31 Q33 A38 A45 K46 K47 R48 R49 F50 N51 W52 S53 K55 A56 R58 R59 T62 R74 G84 S85 T86 P87 K88	G1 K2 K5 G6 T7 S9 F10 G11 K12 R13 N14 G15 K16 T17 H18 K26 R27 H30 Q32 A37 A44 K45 K46 R47 R48 F49 N50 W51 S52 K54 A55 R57 R58 T61 R73 G83 S84 T85 P86 K87
BS02	rna	c	K17 F20 L23 R24 C25 G26 Y30 L32 Y42 A45 T62 T64 G65 R66 C67 R68 Y69 I70 K71 L73 R75 K76 N79 F81 G84 S85 P87 K88 P89 K90	K16 F19 L22 R23 C24 G25 Y29 L31 Y41 A44 T61 T63 G64 R65 C66 R67 Y68 I69 K70 L72 R74 K75 N78 F80 G83 S84 P86 K87 P88 K89
BS03	ZN	c	C37 C40	C36 C39

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0003735	structural constituent of ribosome
GO:0019843	rRNA binding
GO:0046872	metal ion binding

	Biological Process
GO:0006412	translation

	Cellular Component
GO:0005840	ribosome
GO:0022625	cytosolic large ribosomal subunit
GO:1990904	ribonucleoprotein complex

External links