Structure of PDB 8va2 Chain b

Receptor sequence

>8va2b (length=419) Species: 9606 (Homo sapiens)

ECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPDSFNTFFSETGAGKH
VPRAVFVDLEPTVIDEVRTGTYRQLFHPEQLITNYARGHYTIGKEIIDLV
LDRIRKLADQCTGLQGFLVFHSFGGGTGSGFTSLLMERLSVDYGKKSKLE
FSIYPAPQVSTAVVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLD
IERPTYTNLNRLISQIVSSITASLRFDGALNVDLTDFQTNLVPYPRIHFP
LATYAPVISAEKAYHEQLSVAEITNACFEPANQMVKCDPRHGKYMACCLL
YRGDVVPKDVNAAIATIKTKRSIQFVDWCPTGFKVGINYQPPTVVPGGDL
AKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEF
SEAREDMAALEKDYEEVGV

3D structure

• PDB: 8va2 Symmetry expanded map of 2 gamma-tubulins bound to 2 alpha tubulins.
• Chain: b
• Resolution: 4.5 Å

Enzymatic activity

• Enzyme Commision number: 3.6.5.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	GTP	b	G10 Q11 A12 Q15 S140 G143 G144 T145 G146 Y224 N228	G8 Q9 A10 Q13 S122 G125 G126 T127 G128 Y206 N210

Gene Ontology

Molecular Function

• GO:0003725 double-stranded RNA binding
• GO:0003924 GTPase activity
• GO:0005198 structural molecule activity
• GO:0005200 structural constituent of cytoskeleton
• GO:0005515 protein binding
• GO:0005525 GTP binding
• GO:0016787 hydrolase activity
• GO:0031625 ubiquitin protein ligase binding

Biological Process

• GO:0000226 microtubule cytoskeleton organization
• GO:0000278 mitotic cell cycle
• GO:0007017 microtubule-based process
• GO:0030705 cytoskeleton-dependent intracellular transport
• GO:0051301 cell division
• GO:0071353 cellular response to interleukin-4

Cellular Component

• GO:0005737 cytoplasm
• GO:0005856 cytoskeleton
• GO:0005874 microtubule
• GO:0005881 cytoplasmic microtubule
• GO:0015630 microtubule cytoskeleton

External links

• PDB: RCSB:8va2, PDBe:8va2, PDBj:8va2
• PDBsum: 8va2
• UniProt: P68363|TBA1B_HUMAN Tubulin alpha-1B chain (Gene Name=TUBA1B)