Structure of PDB 8sfe Chain b

Receptor sequence
>8sfeb (length=478) Species: 9606 (Homo sapiens) [Search protein sequence]
ARLTSFIGAIAIGDLVKSTLGPKGMDKILLSSGRDASLMVTNDGATILKN
IGVDNPAAKVLVDMSRVQDDEVGDGTTSVTVLAAELLREAESLIAKKIHP
QTIIAGWREATKAAREALLSSAVDHGSDEVKFRQDLMNIAGTTLSSKLLT
HHKDHFTKLAVEAVLRLKGSGNLEAIHIIKKLGGSLADSYLDEGFLLDKK
IGVNQPKRIENAKILIANTGKVAEIEHAEKEKMKEKVERILKHGINCFIN
RQLIYNYPEQLFGAAGVMAIEHADFAGVERLALVTGGEIASTFDHPELVK
LGSCKLIEEVMIGEDKLIHFSGVALGEACTIVLRGATQQILDEAERSLHD
ALCVLAQTVKDSRTVYGGGCSEMLMAHAVTQLANRTPGKEAVAMESYAKA
LRMLPTIIADNAGYDSADLVAQLRAAHSEGNTTAGLDMREGTIGDMAILG
ITESFQVKRQVLLSAAEAAEVILRVDNI
3D structure
PDB8sfe Visualizing the chaperone-mediated folding trajectory of the G protein beta 5
Chainb
Resolution3.36 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP b G44 P45 D97 T100 G410 M480 G21 P22 D74 T77 G368 M438
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
GO:0031625 ubiquitin protein ligase binding
GO:0044183 protein folding chaperone
GO:0051082 unfolded protein binding
GO:0140662 ATP-dependent protein folding chaperone
Biological Process
GO:0006457 protein folding
GO:0007339 binding of sperm to zona pellucida
GO:0032212 positive regulation of telomere maintenance via telomerase
GO:0050821 protein stabilization
GO:0051086 chaperone mediated protein folding independent of cofactor
GO:0051131 chaperone-mediated protein complex assembly
GO:0061077 chaperone-mediated protein folding
GO:0090666 scaRNA localization to Cajal body
GO:1904871 positive regulation of protein localization to Cajal body
GO:1904874 positive regulation of telomerase RNA localization to Cajal body
Cellular Component
GO:0002199 zona pellucida receptor complex
GO:0005576 extracellular region
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005832 chaperonin-containing T-complex
GO:0005874 microtubule
GO:0035578 azurophil granule lumen
GO:0044297 cell body
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8sfe, PDBe:8sfe, PDBj:8sfe
PDBsum8sfe
PubMed37852256
UniProtP78371|TCPB_HUMAN T-complex protein 1 subunit beta (Gene Name=CCT2)

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