Structure of PDB 8ipx Chain b

Receptor sequence

>8ipxb (length=176) Species: 9606 (Homo sapiens)

MKASGTLREYKVVGRCLPTPKCHTPPLYRMRIFAPNHVVAKSRFWYFVSQ
LKKMKKSSGEIVYCGQVFEKSPLRVKNFGIWLRYDSRSGTHNMYREYRDL
TTAGAVTQCYRDMGARHRARAHSIQIMKVEEIAASKCRRPAVKQFHDSKI
KFPLPHRVLRRQHKPRFTTKRPNTFF

3D structure

• PDB: 8ipx Visualizing the nucleoplasmic maturation of human pre-60S ribosomal particles.
• Chain: b
• Resolution: 4.3 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	b	K2 A3 S4 G5 Y63 Q66 F68 K70 P72 L73 R87 S88 R95 R111 G114 A115 R116 H117 R118 R120 R139 H146 D147 S148 P155 H156 V158 R160 R161 H163 P165 R166 T168 T169 K170 P172 N173 T174 F175 F176	K2 A3 S4 G5 Y63 Q66 F68 K70 P72 L73 R87 S88 R95 R111 G114 A115 R116 H117 R118 R120 R139 H146 D147 S148 P155 H156 V158 R160 R161 H163 P165 R166 T168 T169 K170 P172 N173 T174 F175 F176
BS02	rna	b	S42 Y46 S49 K52 K53 K55 K56 S57 R87 H122	S42 Y46 S49 K52 K53 K55 K56 S57 R87 H122

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0005515 protein binding

Biological Process

• GO:0002181 cytoplasmic translation
• GO:0006412 translation

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0005840 ribosome
• GO:0016020 membrane
• GO:0022625 cytosolic large ribosomal subunit
• GO:0022626 cytosolic ribosome
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:8ipx, PDBe:8ipx, PDBj:8ipx
• PDBsum: 8ipx
• PubMed: 37491604
• UniProt: Q02543|RL18A_HUMAN Large ribosomal subunit protein eL20 (Gene Name=RPL18A)