Structure of PDB 7zxe Chain b

Receptor sequence
>7zxeb (length=365) Species: 9606 (Homo sapiens) [Search protein sequence]
NFPEYELPELNTRAFHVGAFGELWRGRLRGAGDLSLREPPAADSDREDAA
VARDLDCSLEAAAELRAVCGLDEVIPENTDLVTLGVRKRFLEHREETITI
DRACRQETFVYEMESHAIGKKPENSADMIEEGELILSVNILYPVIFHKHK
EHKPYQTMLVLGSQKLTQLRDSIRCVSDLQIGGEFSNTPDQAPEHISKDL
YKSAFFYFEGTFYNDKRYPECRDLSRTIIEWSESHDRGYGKFQTARMEDF
TFNDLCIKLGFPYLYCHQGDCEHVIVITDIRLVHHDDCLDRTLYPLLIKK
HWLWTRKCFVCKMYTARWVTNNDSFAPEDPCFFCDVCFRMLHYDSEGNKL
GEFLAYPYVDPGTFN
3D structure
PDB7zxe Structural basis of SNAPc-dependent snRNA transcription initiation by RNA polymerase II.
Chainb
Resolution3.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna b R140 I144 I146 C150 Q152 K194 H198 H347 R94 I98 I100 C104 Q106 K148 H152 H301
BS02 dna b R148 R151 K199 W350 K353 R102 R105 K153 W304 K307
BS03 ZN b C221 H313 H319 C175 H267 H273
BS04 ZN b C354 C357 C383 C308 C311 C337
Gene Ontology
Molecular Function
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000995 RNA polymerase III general transcription initiation factor activity
GO:0001006 RNA polymerase III type 3 promoter sequence-specific DNA binding
GO:0001046 core promoter sequence-specific DNA binding
GO:0003677 DNA binding
GO:0003681 bent DNA binding
GO:0005515 protein binding
Biological Process
GO:0006366 transcription by RNA polymerase II
GO:0006383 transcription by RNA polymerase III
GO:0009301 snRNA transcription
GO:0042795 snRNA transcription by RNA polymerase II
GO:0042796 snRNA transcription by RNA polymerase III
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0016604 nuclear body
GO:0019185 snRNA-activating protein complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7zxe, PDBe:7zxe, PDBj:7zxe
PDBsum7zxe
PubMed36424526
UniProtQ92966|SNPC3_HUMAN snRNA-activating protein complex subunit 3 (Gene Name=SNAPC3)

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