Structure of PDB 7uqz Chain b

Receptor sequence

>7uqzb (length=642) Species: 1247190 (Saccharomyces cerevisiae BY4741) [Search protein sequence]

MQLSWKDIPTVAPANDLLDIVLNRTQRKTPTVIRPGFKITRIRAFYMRKV
KYTGEGFVEKFEDILKGFPNINDVHPFHRDLMDTLYEKNHYKISLAAISR
AKSLVEQVARDYVRLLKFGQSLFQCKQLKRAALGRMATIVKKLRDPLAYL
EQVRQHIGRLPSIDPNTRTLLICGYPNVGKSSFLRCITKSDVDVQPYAFT
TKSLYVGHFDYKYLRFQAIDTPGILDRPTEEMNNIEMQSIYAIAHLRSCV
LYFMDLSEQCGFTIEAQVKLFHSIKPLFANKSVMVVINKTDIIRPEDLDE
ERAQLLESVKEVPGVEIMTSSCQLEENVMEVRNKACEKLLASRIENKLKS
QSRINNVLNKIHVAQPQARDDVKRTPFIPESVKNLKKYDPEDPNRRKLAR
DIEAENGGAGVFNVNLKDKYLLEDDEWKNDIMPEILDGKNVYDFLDPEIA
AKLQALEEEEEKLENEGFYNEIYDGFEASEVDDIKEKAAWIRNRQKTMIA
EARNRKSLKNKAIMPRSKLTKSFGKMEEHMSTLGHDMSALQDKQNRAARK
NRYVERGSDVVFGDQDALTASTENGVKLRQTDRLLDGVADGSMRSKADRM
AKMERRERNRHAKQGESDRHNAVSLSKHLFSGKRGVGKTDFR

3D structure

PDB

7uqz rRNA methylation by Spb1 regulates the GTPase activity of Nog2 during 60S ribosomal subunit assembly.

Chain

Resolution

2.44 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	rna	b	K6 D19 I20 L22 N23 Q26 R27 K28 T31 V32 I33 R34 P35 G36 K38 R41 R43 Y46 M47 R48 K49 P69 N70 I71 N89 Y91 K92 I93 L95 A96 R100 L104 R114 K117 L122 F123 K126 K129 R130 A131 G134 R135 I139 Q155 R159 S162 K189 Y197 F199 K202 V206 H208 R215 R227 G410 V411 Q500 I504 R508 K511 S512 K514 N515 K516 I518 R521 S522 N579 G580 Q585 T586 D587 R588 M605 M608 R610 R611 N614 A617 K618 Q619 R624 H625 H633 R639 V641 G642 K643 T644 D645 R647	K6 D19 I20 L22 N23 Q26 R27 K28 T31 V32 I33 R34 P35 G36 K38 R41 R43 Y46 M47 R48 K49 P69 N70 I71 N89 Y91 K92 I93 L95 A96 R100 L104 R114 K117 L122 F123 K126 K129 R130 A131 G134 R135 I139 Q155 R159 S162 K189 Y197 F199 K202 V206 H208 R215 R227 G410 V411 Q495 I499 R503 K506 S507 K509 N510 K511 I513 R516 S517 N574 G575 Q580 T581 D582 R583 M600 M603 R605 R606 N609 A612 K613 Q614 R619 H620 H628 R634 V636 G637 K638 T639 D640 R642
BS02	rna	b	D591 G592	D586 G587
BS03	GDP	b	N177 V178 G179 K180 S181 S182 V194 Q195 N288 K289 D291 C322 Q323	N177 V178 G179 K180 S181 S182 V194 Q195 N288 K289 D291 C322 Q323
BS04	MG	b	S181 T201	S181 T201

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0003924	GTPase activity
GO:0005515	protein binding
GO:0005525	GTP binding

	Biological Process
GO:0000054	ribosomal subunit export from nucleus
GO:0006364	rRNA processing
GO:0042254	ribosome biogenesis
GO:0042273	ribosomal large subunit biogenesis
GO:1902626	assembly of large subunit precursor of preribosome

	Cellular Component
GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0030687	preribosome, large subunit precursor

View graph for
Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:7uqz, PDBe:7uqz, PDBj:7uqz
PDBsum	7uqz
PubMed	36864048
UniProt	Q02892\|NOG1_YEAST Nucleolar GTP-binding protein 1 (Gene Name=NOG1)

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