Structure of PDB 7u0h Chain b

Receptor sequence

>7u0hb (length=546) Species: 1247190 (Saccharomyces cerevisiae BY4741) [Search protein sequence]

MQLSWKDIPTVAPANDLLDIVLNRTQRKTPTVIRPGFKITRIRAFYMRKV
KYTGEGFVEKFEDILKGFPNINDVHPFHRDLMDTLYEKNHYKISLAAISR
AKSLVEQVARDYVRLLKFGQSLFQCKQLKRAALGRMATIVKKLRDPLAYL
EQVRQHIGRLPSIDPNTRTLLICGYPNVGKSSFLRCITKSDVDVQPYAFT
TKSLYVGHFDYKYLRFQAIDTPGILDRPTEEMNNIEMQSIYAIAHLRSCV
LYFMDLSEQCGFTIEAQVKLFHSIKPLFANKSVMVVINKTDIIRPEDLDE
ERAQLLESVKEVPGVEIMTSSCQLEENVMEVRNKACEKLLASRIENKLKS
QSRINNVLNKIHVAQPQARDDVKRTPFIPESVKNLKKYDPEDPNRRKLAR
DIEAENGGAGVFNVNLKDKYLLEDDEWKNDIMPEILDGKNVYDFLDPEIA
AKLQALEEEEEKLENEGFYNEIYDGFEASEVDDIKEKAAWIRNRQKTMIA
EARNRKSLKNKAIMPRSKLTKSFGKMEEHMSTLGHDMSALQDKQNR

3D structure

PDB

7u0h Sequence-specific remodeling of a topologically complex RNP substrate by Spb4.

Chain

Resolution

2.76 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	rna	b	K6 D19 I20 L22 N23 Q26 R27 K28 T31 V32 I33 R34 P35 Y46 K49 L65 N89 K92 I93 L95 R100 L104 Q107 V108 K117 F123 K126 K129 R130 L133 G134 R135 T138 R154 Q155 R159 S162 K189 Y197 F199 K202 H208 N233 I235 G410 V411 I504 R508 K511 S512 K514 N515 I518 R521	K6 D19 I20 L22 N23 Q26 R27 K28 T31 V32 I33 R34 P35 Y46 K49 L65 N89 K92 I93 L95 R100 L104 Q107 V108 K117 F123 K126 K129 R130 L133 G134 R135 T138 R154 Q155 R159 S162 K189 Y197 F199 K202 H208 N233 I235 G410 V411 I499 R503 K506 S507 K509 N510 I513 R516
BS02	peptide	b	H245 P276 L277	H245 P276 L277
BS03	MG	b	P176 N177 Y197 T200	P176 N177 Y197 T200

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0003924	GTPase activity
GO:0005515	protein binding
GO:0005525	GTP binding

	Biological Process
GO:0000054	ribosomal subunit export from nucleus
GO:0006364	rRNA processing
GO:0042254	ribosome biogenesis
GO:0042273	ribosomal large subunit biogenesis
GO:1902626	assembly of large subunit precursor of preribosome

	Cellular Component
GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0030687	preribosome, large subunit precursor

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:7u0h, PDBe:7u0h, PDBj:7u0h
PDBsum	7u0h
PubMed	36482249
UniProt	Q02892\|NOG1_YEAST Nucleolar GTP-binding protein 1 (Gene Name=NOG1)

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