Structure of PDB 7elw Chain b

Receptor sequence

>7elwb (length=676) Species: 9823 (Sus scrofa)

LEEMLTQAVQEADIEQVRQLLERGADANFQEEEWGWSPLHSAVQMDSEDL
VALLLKHGADPCLRKRNGATPFIIAGITGNVRLLQLLLPNVEDVNECDVN
GFTAFMEAAVYGRVEALRFLYENGADVNMHRKTKQDQERIRKGGATALMD
AAEKGHVGVVTILLHAMKAEVDARDNMGRNALVYALLNPDDGKAKAITRL
LLDHGADVNVRGEGSKTPLILAVERKNLDLVQMLLEQEQIEVNDTDREGK
TALLLAVELRLEEIAKLLCHRGASTNCGDLVAIARRNYDSDLVKFLRLHN
WKPQSSRWGEALKHLHRIWRPMIGKLKIFIDEEYKIADTAEGGIYLGLYE
DQEVAVKRFSEGSTRGQQEVSCLQSSRANDNVVTFYGSESDGSCLHVCLA
LCEYTLQEHLANHRGDAVPNEEDESARNILSSLFKAIGELHRSGYSHQDL
QPQNILIDSKNGTFLADFDKSIKWAEDPQKIKRDLEALGLLVLYVVKKGD
ISFETLKNQSFEEVIQGSPDEETRDLIHHLFHPGDNVEDRLSSLLAHPFF
WSWESRYRTLRDVGNESDIKTRNQNSRILQLLQPGTESTSFAQWTTKIDS
FVMEEMNAYNLYQDTLGDLLKFIRNLGEHINEQKNKKMKSIIGEPSQYFQ
EKFPDLVMYVYTKLQNTEYMKHFPKT

3D structure

• PDB: 7elw Identification of Small Molecule Inhibitors of RNase L by Fragment-Based Drug Discovery
• Chain: b
• Resolution: 3.55 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	25L	b	R307 Y310 R353	R285 Y288 R320
BS02	25L	b	W56 W58 Q66 K87 N122 F124 E129 Y133 R153	W34 W36 Q44 K65 N100 F102 E107 Y111 R131
BS03	MYC	b	R340 I369 A370 A388 L432 A433 C435 T438 E441 L489 A499 D500	R307 I336 A337 A355 L399 A400 C402 T405 E408 L456 A466 D467

Gene Ontology

Molecular Function

• GO:0004540 RNA nuclease activity
• GO:0004672 protein kinase activity
• GO:0005524 ATP binding
• GO:0046872 metal ion binding

Biological Process

• GO:0006397 mRNA processing
• GO:0006468 protein phosphorylation

External links

• PDB: RCSB:7elw, PDBe:7elw, PDBj:7elw
• PDBsum: 7elw
• UniProt: A5H025