Structure of PDB 7dsy Chain b

Receptor sequence
>7dsyb (length=676) Species: 9823 (Sus scrofa) [Search protein sequence]
LEEMLTQAVQEADIEQVRQLLERGADANFQEEEWGWSPLHSAVQMDSEDL
VALLLKHGADPCLRKRNGATPFIIAGITGNVRLLQLLLPNVEDVNECDVN
GFTAFMEAAVYGRVEALRFLYENGADVNMHRKTKQDQERIRKGGATALMD
AAEKGHVGVVTILLHAMKAEVDARDNMGRNALVYALLNPDDGKAKAITRL
LLDHGADVNVRGEGSKTPLILAVERKNLDLVQMLLEQEQIEVNDTDREGK
TALLLAVELRLEEIAKLLCHRGASTNCGDLVAIARRNYDSDLVKFLRLHN
WKPQSSRWGEALKHLHRIWRPMIGKLKIFIDEEYKIADTAEGGIYLGLYE
DQEVAVKRFSEGSTRGQQEVSCLQSSRANDNVVTFYGSESDGSCLHVCLA
LCEYTLQEHLANHRGDAVPNEEDESARNILSSLFKAIGELHRSGYSHQDL
QPQNILIDSKNGTFLADFDKSIKWAEDPQKIKRDLEALGLLVLYVVKKGD
ISFETLKNQSFEEVIQGSPDEETRDLIHHLFHPGDNVEDRLSSLLAHPFF
WSWESRYRTLRDVGNESDIKTRNQNSRILQLLQPGTLSTSFAQWTTKIDS
FVMEEMNAYNLYQDTLGDLLKFIRNLGEHINEQKNKKMKSIIGEPSQYFQ
EKFPDLVMYVYTKLQNTEYMKHFPKT
3D structure
PDB7dsy Identification of Small Molecule Inhibitors of RNase L by Fragment-Based Drug Discovery
Chainb
Resolution2.651 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 25A b R307 R308 Y310 R353 R285 R286 Y288 R320
BS02 25A b W56 W58 S63 K87 N89 N122 F124 E129 Y133 W34 W36 S41 K65 N67 N100 F102 E107 Y111
BS03 HFX b I369 L489 I336 L456
Gene Ontology
Molecular Function
GO:0004540 RNA nuclease activity
GO:0004672 protein kinase activity
GO:0005524 ATP binding
GO:0046872 metal ion binding
Biological Process
GO:0006397 mRNA processing
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7dsy, PDBe:7dsy, PDBj:7dsy
PDBsum7dsy
PubMed
UniProtA5H025

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