Structure of PDB 7a08 Chain b

Receptor sequence
>7a08b (length=105) Species: 9606 (Homo sapiens) [Search protein sequence]
KAKSRSSRAGLQFPVGRVHRLLRKGNYAERVGAGAPVYLAAVLEYLTAEI
LELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGRVTIAQGGVLPNIQ
AVLLP
3D structure
PDB7a08 Structural basis for sequestration and autoinhibition of cGAS by chromatin.
Chainb
Resolution3.11 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna b A14 K15 S16 R17 R32 R77 A2 K3 S4 R5 R20 R65
BS02 dna b R29 R42 V43 G44 A45 T76 R77 R17 R30 V31 G32 A33 T64 R65
Gene Ontology
Molecular Function
GO:0003674 molecular_function
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0030527 structural constituent of chromatin
GO:0031492 nucleosomal DNA binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0008285 negative regulation of cell population proliferation
GO:0031507 heterochromatin formation
Cellular Component
GO:0000786 nucleosome
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0070062 extracellular exosome

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Cellular Component
External links
PDB RCSB:7a08, PDBe:7a08, PDBj:7a08
PDBsum7a08
PubMed32911480
UniProtQ93077|H2A1C_HUMAN Histone H2A type 1-C (Gene Name=H2AC6)

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