Structure of PDB 6m13 Chain b

Receptor sequence
>6m13b (length=688) Species: 9823 (Sus scrofa) [Search protein sequence]
LEEMLTQAVQEADIEQVRQLLERGADANFQEEEWGWSPLHSAVQMDSEDL
VALLLKHGADPCLRKRNGATPFIIAGITGNVRLLQLLLPNVEDVNECDVN
GFTAFMEAAVYGRVEALRFLYENGADVNMHRKTKQDQERIRKGGATALMD
AAEKGHVGVVTILLHAMKAEVDARDNMGRNALVYALLNPDDGKAKAITRL
LLDHGADVNVRGEGSKTPLILAVERKNLDLVQMLLEQEQIEVNDTDREGK
TALLLAVELRLEEIAKLLCHRGASTNCGDLVAIARRNYDSDLVKFLRLHA
GEDFRPPAENWKPQSSRWGEALKHLHRIWRPMIGKLKIFIDEEYKIADTA
EGGIYLGLYEDQEVAVKRFSEGSTRGQQEVSCLQSSRANDNVVTFYGSES
DGSCLHVCLALCEYTLQEHLANHRGDAVPNEEDESARNILSSLFKAIGEL
HRSGYSHQDLQPQNILIDSKNGTFLADFDKSIKWAEDPQKIKRDLEALGL
LVLYVVKKGDISFETLKNQSFEEVIQGSPDEETRDLIHHLFHPGVEDRLS
SLLAHPFFWSWESRYRTLRDVGNESDIKTRNQNSRILQLLQPGTSELSTS
FAQWTTKIDSFVMEEMNAGNLYQDTLGDLLKFIRNLGEHINEQKNKKMKS
IIGEPSQYFQEKFPDLVMYVYTKLQNTEYMKHFPKTHN
3D structure
PDB6m13 Sunitinib inhibits RNase L by destabilizing its active dimer conformation.
Chainb
Resolution2.56 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 25L b R307 R308 Y310 R353 R285 R286 Y288 R330
BS02 BWC b I369 A370 A388 E441 L489 I346 A347 A365 E418 L466
BS03 25L b W56 W58 S63 K87 N89 N122 F124 E129 R153 W34 W36 S41 K65 N67 N100 F102 E107 R131
Gene Ontology
Molecular Function
GO:0004540 RNA nuclease activity
GO:0004672 protein kinase activity
GO:0005524 ATP binding
GO:0046872 metal ion binding
Biological Process
GO:0006397 mRNA processing
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:6m13, PDBe:6m13, PDBj:6m13
PDBsum6m13
PubMed32830849
UniProtA5H025

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