Structure of PDB 6m11 Chain b

Receptor sequence
>6m11b (length=684) Species: 9823 (Sus scrofa) [Search protein sequence]
LEEMLTQAVQEADIEQVRQLLERGADANFQEEEWGWSPLHSAVQMDSEDL
VALLLKHGADPCLRKRNGATPFIIAGITGNVRLLQLLLPNVEDVNECDVN
GFTAFMEAAVYGRVEALRFLYENGADVNMHRKTKQDQERIRKGGATALMD
AAEKGHVGVVTILLHAMKAEVDARDNMGRNALVYALLNPDDGKAKAITRL
LLDHGADVNVRGEGSKTPLILAVERKNLDLVQMLLEQEQIEVNDTDREGK
TALLLAVELRLEEIAKLLCHRGASTNCGDLVAIARRNYDSDLVKFLRLHA
GEDFPPANWKPQSSRWGEALKHLHRIWRPMIGKLKIFIDEEYKIADTAEG
GIYLGLYEDQEVAVKRFSEGSTRGQQEVSCLQSSRANDNVVTFYGSESDG
SCLHVCLALCEYTLQEHLANHRGDAVPNEEDESARNILSSLFKAIGELHR
SGYSHQDLQPQNILIDSKNGTFLADFDKSIKWAEDPQKIKRDLEALGLLV
LYVVKKGDISFETLKNQSFEEVIQGSPDEETRDLIHHLFHPGDNVEDRLS
SLLAHPFFWSWESRYRTLRDVGNESDIKTRNQNSRILQLLQPGTESTSFA
QWTTKIDSFVMEEMNAYNLYQDTLGDLLKFIRNLGEHINEQKNKKMKSII
GEPSQYFQEKFPDLVMYVYTKLQNTEYMKHFPKT
3D structure
PDB6m11 Sunitinib inhibits RNase L by destabilizing its active dimer conformation.
Chainb
Resolution2.46 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 25A b R307 Y310 R353 R285 Y288 R328
BS02 25A b W58 K87 N122 F124 E129 R153 W36 K65 N100 F102 E107 R131
BS03 B49 b R340 I369 A370 A388 L432 L489 R315 I344 A345 A363 L407 L464
Gene Ontology
Molecular Function
GO:0004540 RNA nuclease activity
GO:0004672 protein kinase activity
GO:0005524 ATP binding
GO:0046872 metal ion binding
Biological Process
GO:0006397 mRNA processing
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:6m11, PDBe:6m11, PDBj:6m11
PDBsum6m11
PubMed32830849
UniProtA5H025

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