Structure of PDB 6hwh Chain b

Receptor sequence

>6hwhb (length=536) Species: 246196 (Mycolicibacterium smegmatis MC2 155)

SPDFAKLAAAQGDAIDSRYHPSAAVRRQLNKVFPTHWSFLLGEIALYSFI
ILLLTGVWLTLFFDPSMAHVTYDGVYQPLRGVQMSRAYETALDISFEVRG
GLFVRQVHHWAALMFAASIMVHLARIFFTGAFRRPREANWVIGSLLLILA
MFEGFFGYSLPDDLLSGTGIRAALSGITMGIPVIGTWMHWALFGGDFPGE
ILIPRLYALHILLIPGIILALIGAHLALVWFQKHTQFPGPGRTETNVVGV
RVMPVFAVKSGAFFAMITGVLGLMGGLLTINPIWNLGPYKPSQVSAGSQP
DFYMMWTDGLIRLWPAWEFYPFGHTIPQGVWVAVGMGLVFALLIAYPFIE
KKVTGDDAHHNLLQRPRDVPVRTAIGSMAIALYLLLTFACMNDIIALKFH
ISLNATTWIGRIGMVVLPAIVYFVAYRWAISLQRSDREVLEHGVETGIIK
RLPHGAYVELHQPLGPVDEHGHPIPLEYAGAPLPKRMNKLGSGGAPGTGS
FLFPDPAVEHEALTEAAHASEHKSLTALKEHQDRIH

3D structure

• PDB: 6hwh Structure of a functional obligate complex III2IV2respiratory supercomplex from Mycobacterium smegmatis.
• Chain: b
• Resolution: 3.3 Å

Enzymatic activity

• Enzyme Commision number: 7.1.1.8: quinol--cytochrome-c reductase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	MQ9	b	M121 L124 F303 V340 A380 I381 Y384 L385	M120 L123 F302 V339 A379 I380 Y383 L384
BS02	HEM	b	F40 G43 A46 L47 I120 H123 L124 R126 I127 W141 G144 I223 H226 L227 V230 H235 T236	F39 G42 A45 L46 I119 H122 L123 R125 I126 W140 G143 I222 H225 L226 V229 H234 T235
BS03	HEM	b	F50 L53 L54 G57 L60 T61 R106 H109 H110 A113 E154 G155 G158 Y159 P162 H211 I212 P216	F49 L52 L53 G56 L59 T60 R105 H108 H109 A112 E153 G154 G157 Y158 P161 H210 I211 P215
BS04	MQ9	b	R28 Q29 E44 G224 A225 L227 W231 F232	R27 Q28 E43 G223 A224 L226 W230 F231
BS05	MQ9	b	Y20 H21	Y19 H20

Gene Ontology

Molecular Function

• GO:0008121 ubiquinol-cytochrome-c reductase activity
• GO:0009055 electron transfer activity
• GO:0016491 oxidoreductase activity

Biological Process

• GO:0022904 respiratory electron transport chain
• GO:1902600 proton transmembrane transport

Cellular Component

• GO:0016020 membrane

External links

• PDB: RCSB:6hwh, PDBe:6hwh, PDBj:6hwh
• PDBsum: 6hwh
• PubMed: 30518849
• UniProt: A0R052