Structure of PDB 8w8e Chain a

Receptor sequence
>8w8ea (length=506) Species: 9606 (Homo sapiens) [Search protein sequence]
KIPPRWLNCPRRGQPVAGRFLPLKTMLGPRYDSQVAEENRFHPSMLSNYL
KSLKVKMGLLVDLTNTSRFYDRNDIEKEGIKYIKLQCKGHGECPTTENTE
TFIRLCERFPELIGVHCTHGFNRTGFLICAFLVEKMDWSIEAAVATFAQA
RPPGIYKGDYLKELFRRYGDIEEAPPPPLLPDWCFEDDEGAIFLEGVTVK
GVTQVTTQPKLGEVQQKCHQFCGWEGSGFPGAQPVSMDKQNIKLLDLKPY
KVSWKADGTRYMMLIDGTNEVFMIDRDNSVFHVSNLEFPFRKDLRMHLSN
TLLDGEMIIDRVNGQAVPRYLIYDIIKFNSQPVGDCDFNVRLQCIEREII
SPRHEKMKTGLIDKTQEPFSVRNKPFFDICTSRKLLEHEMDGLIFQPTGK
YKPGRCDDILKWKPPSLNSVDFRLKITRMGGEGLLPQNVGLLYVGGYERP
FAQIKVTKELKQYDNKIIECKFENNSWVFMRQRTDKSFPNAYNTAMAVCN
SISNPV
3D structure
PDB8w8e Strcutures of co-transcriptional RNA capping enzymes on paused transcription complex
Chaina
Resolution3.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.50: mRNA guanylyltransferase.
3.6.1.74: mRNA 5'-phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GTP a N69 T70 R72 N65 T66 R68
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004484 mRNA guanylyltransferase activity
GO:0004651 polynucleotide 5'-phosphatase activity
GO:0004721 phosphoprotein phosphatase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0005525 GTP binding
GO:0008192 RNA guanylyltransferase activity
GO:0016779 nucleotidyltransferase activity
GO:0050355 inorganic triphosphate phosphatase activity
GO:0140818 mRNA 5'-triphosphate monophosphatase activity
Biological Process
GO:0006139 nucleobase-containing compound metabolic process
GO:0006370 7-methylguanosine mRNA capping
GO:0006396 RNA processing
GO:0006470 protein dephosphorylation
GO:0016311 dephosphorylation
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8w8e, PDBe:8w8e, PDBj:8w8e
PDBsum8w8e
PubMed38816438
UniProtO60942|MCE1_HUMAN mRNA-capping enzyme (Gene Name=RNGTT)

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