Structure of PDB 8w2f Chain a

Receptor sequence
>8w2fa (length=211) Species: 36329 (Plasmodium falciparum 3D7) [Search protein sequence]
WYPYIDNGGTVIGLTGKDYVILAADTRLSLSYSIYTRFCPKISKLTDKCI
IGSSGMQSDIKTLHSLLQKKIQLFVLEHSHYPDIHVIARLLCVILYSRRF
FPYYAFNILAGVDENNKGVLYNYDSVGSYCEATHSCVGSGSQLILPILDN
RVEQKNQLIKNTNFNLGDDINFVKDAITSATERDIYTGDKTLIYVIDKMG
INVNTLDLKQD
3D structure
PDB8w2f Identification of potent and reversible piperidine carboxamides that are species-selective orally active proteasome inhibitors to treat malaria
Chaina
Resolution3.1 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 A1AE6 a S83 G84 F135 N151 Y152 S157 Y158 C159 G167 S170 Q171 L174 S54 G55 F106 N122 Y123 S128 Y129 C130 G138 S141 Q142 L145
Gene Ontology
Molecular Function
GO:0016787 hydrolase activity
Biological Process
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
Cellular Component
GO:0000502 proteasome complex
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0019774 proteasome core complex, beta-subunit complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8w2f, PDBe:8w2f, PDBj:8w2f
PDBsum8w2f
PubMed39084225
UniProtA0A5K1K7U1

[Back to BioLiP]