Structure of PDB 7ut1 Chain a

Receptor sequence

>7ut1a (length=264) Species: 11757 (Mouse mammary tumor virus)

ALESAQESHALHHQNAAALRFQFHITREQAREIVKLCPNCPDWGHAPQLG
VNPRGLKPRVLWQMDVTHVSEFGKLKYVHVTVDTYSHFTFATARTGEATK
DVLQHLAQSFAYMGIPQKIKTDNAPAYVSRSIQEFLARWKISHVTGIPYN
PQGQAIVERTHQNIKAQLNKLQKAGKYYTPHHLLAHALFVLNHVNMDNQG
HTAAERHWGPISADPKPMVMWKDLLTGSWKGPDVLITAGRGYACVFPQDA
ESPIWVPDRFIRPF

3D structure

• PDB: 7ut1 B-to-A transition in target DNA during retroviral integration.
• Chain: a
• Resolution: 3.8 Å

Enzymatic activity

• Enzyme Commision number: 2.7.7.-
  2.7.7.49: RNA-directed DNA polymerase.
  2.7.7.7: DNA-directed DNA polymerase.
  3.1.-.-
  3.1.26.4: ribonuclease H.
  3.4.23.-
  3.6.1.23: dUTP diphosphatase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	a	V51 N52 P53 R54 H87 K120 G146 I147 Q152 I156 R159	V51 N52 P53 R54 H87 K120 G146 I147 Q152 I156 R159
BS02	dna	a	H68 P151 Q152 Q162 K165 R240	H68 P151 Q152 Q162 K165 R240
BS03	dna	a	N15 R31 W43 H45	N15 R31 W43 H45
BS04	dna	a	T26 R27 H45 E97 A98 T99 S129	T26 R27 H45 E97 A98 T99 S129
BS05	dna	a	N123 A124 P125 Y149	N123 A124 P125 Y149
BS06	ZN	a	H9 H13 C37	H9 H13 C37

Gene Ontology

Molecular Function

• GO:0003676 nucleic acid binding
• GO:0008270 zinc ion binding

Biological Process

• GO:0015074 DNA integration

External links

• PDB: RCSB:7ut1, PDBe:7ut1, PDBj:7ut1
• PDBsum: 7ut1
• PubMed: 35947647
• UniProt: P03365|POL_MMTVB Gag-Pro-Pol polyprotein (Gene Name=gag-pro-pol)