Structure of PDB 7o3c Chain a

Receptor sequence

>7o3ca (length=514) Species: 10090 (Mus musculus) [Search protein sequence]

MFINRWLFSTNHKDIGTLYLLFGAWAGMVGTALSILIRAELGQPGALLGD
DQIYNVIVTAHAFVMIFFMVMPMMIGGFGNWLVPLMIGAPDMAFPRMNNM
SFWLLPPSFLLLLASSMVEAGAGTGWTVYPPLAGNLAHAGASVDLTIFSL
HLAGVSSILGAINFITTIINMKPPAMTQYQTPLFVWSVLITAVLLLLSLP
VLAAGITMLLTDRNLNTTFFDPAGGGDPILYQHLFWFFGHPEVYILILPG
FGIISHVVTYYSGKKEPFGYMGMVWAMMSIGFLGFIVWAHHMFTVGLDVD
TRAYFTSATMIIAIPTGVKVFSWLATLHGGNIKWSPAMLWALGFIFLFTV
GGLTGIVLSNSSLDIVLHDTYYVVAHFHYVLSMGAVFAIMAGFVHWFPLF
SGFTLDDTWAKAHFAIMFVGVNMTFFPQHFLGLSGMPRRYSDYPDAYTTW
NTVSSMGSFISLTAVLIMIFMIWEAFASKREVMSVSYASTNLEWLHGCPP
PYHTFEEPTYVKVK

3D structure

PDB

7o3c Structure and assembly of the mammalian mitochondrial supercomplex CIII 2 CIV.

Chain

Resolution

3.3 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

7.1.1.9: cytochrome-c oxidase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	CU	a	H240 H290 H291	H240 H290 H291
BS02	HEA	a	A24 T31 I37 R38 Y54 V58 H61 A62 M65 I66 M69 G125 W126 Y371 F377 H378 S382 F393 F425 R438 R439 Y440 V465	A24 T31 I37 R38 Y54 V58 H61 A62 M65 I66 M69 G125 W126 Y371 F377 H378 S382 F393 F425 R438 R439 Y440 V465
BS03	HEA	a	W236 V243 I247 H290 H291 T316 G317 F348 T349 G352 L353 G355 I356 L358 S359 H368 V373 H376 F377 V380 L381 R438	W236 V243 I247 H290 H291 T316 G317 F348 T349 G352 L353 G355 I356 L358 S359 H368 V373 H376 F377 V380 L381 R438

Gene Ontology

	Molecular Function
GO:0004129	cytochrome-c oxidase activity
GO:0020037	heme binding
GO:0046872	metal ion binding

	Biological Process
GO:0001666	response to hypoxia
GO:0006119	oxidative phosphorylation
GO:0006979	response to oxidative stress
GO:0009060	aerobic respiration
GO:0021549	cerebellum development
GO:0046688	response to copper ion
GO:0051602	response to electrical stimulus
GO:1902600	proton transmembrane transport

	Cellular Component
GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0016020	membrane
GO:0031966	mitochondrial membrane
GO:0045277	respiratory chain complex IV

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:7o3c, PDBe:7o3c, PDBj:7o3c
PDBsum	7o3c
PubMed	34616041
UniProt	P00397\|COX1_MOUSE Cytochrome c oxidase subunit 1 (Gene Name=Mtco1)

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