Structure of PDB 7khr Chain a

Receptor sequence
>7khra (length=750) Species: 9913 (Bos taurus) [Search protein sequence]
LFRSEEMTLAQLFLQSEAAYCCVSELGELGKVQFRDLNPDVNVFQRKFVN
EVRRCEEMDRKLRFVEKEIRKANIPIMDTGENPEVPFPRDMIDLEANFEK
IENELKEINTNQEALKRNFLELTELKFILRKTQQFFDRLGFVAGVINRER
IPTFERMLWRVCRGNVFLRQAEIENPLEDPVTGDYVHKSVFIIFFQGDQL
KNRVKKICEGFRASLYPCPETPQERKEMASGVNTRIDDLQMVLNQTEDHR
QRVLQAAAKNIRVWFIKVRKMKAIYHTLNLCNIDVTQKCLIAEVWCPVTD
LDSIQFALRRGTEHSGSTVPSILNRMQTNQTPPTYNKTNKFTYGFQNIVD
AYGIGTYREINPAPYTIITFPFLFAVMFGDLGHGILMTLFAVWMVLRESR
ILSQKNENEMFSTIFSGRYIILLMGVFSIYTGLIYNDCFSKSLNIFGSSW
SVRPMFDIYNWTEETLRGNPVLQLNPAVTGVFGGPYPFGIDPIWNIATNK
LTFLNSFKMKMSVILGIIHMLFGVSLSLFNHTYFKKPLNIYFGFIPEIIF
MTSLFGYLVILIFYKWTAYNAKTSEKAPSLLIHFINMFLFSYGDSGNSML
YSGQKGIQCFLVVVALLCVPWMLLFKPLVFGDTMVHQAIHTIEYCLGCIS
NTASYLRLWALSLAHAQLSEVLWTMVIHIGLKVKSLAGGLALFFIFAAFA
TLTVAILLIMEGLSAFLHALRLHWVEFQNKFYSGTGFKFLPFSFEHIREG
3D structure
PDB7khr Molecular basis of V-ATPase inhibition by bafilomycin A1.
Chaina
Resolution3.62 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MAN a Q502 L503 N504 Q473 L474 N475
BS02 WJP a S535 K539 I591 K594 S608 L609 L610 I614 S506 K510 I562 K565 S579 L580 L581 I585
Gene Ontology
Molecular Function
GO:0046961 proton-transporting ATPase activity, rotational mechanism
GO:0051117 ATPase binding
Biological Process
GO:0007035 vacuolar acidification
GO:0045851 pH reduction
GO:1902600 proton transmembrane transport
Cellular Component
GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016471 vacuolar proton-transporting V-type ATPase complex
GO:0030665 clathrin-coated vesicle membrane
GO:0030672 synaptic vesicle membrane
GO:0031410 cytoplasmic vesicle
GO:0033179 proton-transporting V-type ATPase, V0 domain
GO:0042470 melanosome
GO:0045202 synapse

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7khr, PDBe:7khr, PDBj:7khr
PDBsum7khr
PubMed33741963
UniProtQ29466|VPP1_BOVIN V-type proton ATPase 116 kDa subunit a 1 (Gene Name=ATP6V0A1)

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