Structure of PDB 7elw Chain a

Receptor sequence
>7elwa (length=675) Species: 9823 (Sus scrofa) [Search protein sequence]
SLEEMLTQAVQEADIEQVRQLLERGADANFQEEEWGWSPLHSAVQMDSED
LVALLLKHGADPCLRKRNGATPFIIAGITGNVRLLQLLLPNVEDVNECDV
NGFTAFMEAAVYGRVEALRFLYENGADVNMHRKTKQDQERIRKGGATALM
DAAEKGHVGVVTILLHAMKAEVDARDNMGRNALVYALLNPDDGKAKAITR
LLLDHGADVNVRGEGSKTPLILAVERKNLDLVQMLLEQEQIEVNDTDREG
KTALLLAVELRLEEIAKLLCHRGASTNCGDLVAIARRNYDSDLVKFLRLH
KAENWKPQSSRWGEALKHLHRIWRPMIGKLKIFIDEEYKIADTAEGGIYL
GLYEDQEVAVKRFSEGSTRGQQEVSCLQSSRANDNVVTFYGSESDGSCLH
VCLALCEYTLQEHLANHRGDAVPNEEDESARNILSSLFKAIGELHRSGYS
HQDLQPQNILIDSKNGTFLADFDKSIKWAEDPQKIKRDLEALGLLVLYVV
KKGDISFETLKNQSFEEVIQGSPDEETRDLIHHLFHPGEDRLSSLLAHPF
FWSWESRYRTLRDVGNESDIKTRNQNSRILQLLQPSELSTSFAQWTTKID
SFVMEEMNALYQDTLGDLLKFIRNLGEHINEQKNKKMKSIIGEPSQYFQE
KFPDLVMYVYTKLQNTEYMKHFPKT
3D structure
PDB7elw Identification of Small Molecule Inhibitors of RNase L by Fragment-Based Drug Discovery
Chaina
Resolution3.55 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 25L a W56 W58 Q66 K87 F124 E129 Y133 R153 W35 W37 Q45 K66 F103 E108 Y112 R132
BS02 MYC a R340 I369 A370 A388 L432 C435 T438 E441 L489 D500 R311 I340 A341 A359 L403 C406 T409 E412 L460 D471
BS03 25L a R307 Y310 R353 R286 Y289 R324
Gene Ontology
Molecular Function
GO:0004540 RNA nuclease activity
GO:0004672 protein kinase activity
GO:0005524 ATP binding
GO:0046872 metal ion binding
Biological Process
GO:0006397 mRNA processing
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:7elw, PDBe:7elw, PDBj:7elw
PDBsum7elw
PubMed
UniProtA5H025

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