Structure of PDB 7dts Chain a

Receptor sequence
>7dtsa (length=672) Species: 9823 (Sus scrofa) [Search protein sequence]
SLEEMLTQAVQEADIEQVRQLLERGADANFQEEEWGWSPLHSAVQMDSED
LVALLLKHGADPCLRKRNGATPFIIAGITGNVRLLQLLLPNVEDVNECDV
NGFTAFMEAAVYGRVEALRFLYENGADVNMHRKTKQDQERIRKGGATALM
DAAEKGHVGVVTILLHAMKAEVDARDNMGRNALVYALLNPDDGKAKAITR
LLLDHGADVNVRGEGSKTPLILAVERKNLDLVQMLLEQEQIEVNDTDREG
KTALLLAVELRLEEIAKLLCHRGASTNCGDLVAIARRNYDSDLVKFLRLH
NWKPQSSRWGEALKHLHRIWRPMIGKLKIFIDEEYKIADTAEGGIYLGLY
EDQEVAVKRFSEGSTRGQQEVSCLQSSRANDNVVTFYGSESDGSCLHVCL
ALCEYTLQEHLANHRGDAVPNEEDESARNILSSLFKAIGELHRSGYSHQD
LQPQNILIDSKNGTFLADFDKSIKWAEDPQKIKRDLEALGLLVLYVVKKG
DISFETLKNQSFEEVIQGSPDEETRDLIHHLFHPGEDRLSSLLAHPFFWS
WESRYRTLRDVGNESDIKTRNQNSRILQLLQPSELSTSFAQWTTKIDSFV
MEEMNALYQDTLGDLLKFIRNLGEHINEQKNKKMKSIIGEPSQYFQEKFP
DLVMYVYTKLQNTEYMKHFPKT
3D structure
PDB7dts Identification of Small Molecule Inhibitors of RNase L by Fragment-Based Drug Discovery
Chaina
Resolution2.63 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 25A a W56 W58 Q66 K87 N89 N122 F124 E129 Y133 R153 W35 W37 Q45 K66 N68 N101 F103 E108 Y112 R132
BS02 27K a A388 C435 E436 Y437 L489 A499 D500 A356 C403 E404 Y405 L457 A467 D468
BS03 25A a R307 R308 Y310 R353 F362 R286 R287 Y289 R321 F330
Gene Ontology
Molecular Function
GO:0004540 RNA nuclease activity
GO:0004672 protein kinase activity
GO:0005524 ATP binding
GO:0046872 metal ion binding
Biological Process
GO:0006397 mRNA processing
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:7dts, PDBe:7dts, PDBj:7dts
PDBsum7dts
PubMed
UniProtA5H025

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