Structure of PDB 6r6p Chain a

Receptor sequence

>6r6pa (length=147) Species: 9986 (Oryctolagus cuniculus)

PSRLRKTRKLRGHVSHGHGRIGKHRKHPGGRGNAGGMHHHRINFDKYHPG
YFGKVGMRHYHLKRNQSFCPTVNLDKLWTLVSEQTRVNAAKNKTGAAPII
DVVRSGYYKVLGKGKLPKQPVIVKAKFFSRRAEEKIKGVGGACVLVA

3D structure

• PDB: 6r6p Structural and mutational analysis of the ribosome-arresting human XBP1u.
• Chain: a
• Resolution: 3.1 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	a	P2 S3 R4 R6 K7 T8 R9 K10 R12 G13 H14 V15 H17 G18 H19 G20 R21 I22 G23 K24 H25 R26 K27 H28 P29 R32 G33 N34 G36 M38 H39 H40 H41 R42 I43 N44 K47 Y48 Y52 F53 G54 K55 V56 G57 M58 R59 H60 Y61 H62 L63 K64 R65 N66 Q67 T72 N74 S83 Q85 T86 D102 K110 L112 G113 K114 G115 K116 S130 R131 R132	P1 S2 R3 R5 K6 T7 R8 K9 R11 G12 H13 V14 H16 G17 H18 G19 R20 I21 G22 K23 H24 R25 K26 H27 P28 R31 G32 N33 G35 M37 H38 H39 H40 R41 I42 N43 K46 Y47 Y51 F52 G53 K54 V55 G56 M57 R58 H59 Y60 H61 L62 K63 R64 N65 Q66 T71 N73 S82 Q84 T85 D101 K109 L111 G112 K113 G114 K115 S129 R130 R131

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0006412 translation

Cellular Component

• GO:0005737 cytoplasm
• GO:0005840 ribosome
• GO:0015934 large ribosomal subunit
• GO:0022625 cytosolic large ribosomal subunit
• GO:0043232 intracellular non-membrane-bounded organelle
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:6r6p, PDBe:6r6p, PDBj:6r6p
• PDBsum: 6r6p
• PubMed: 31246176
• UniProt: G1SNY0|RL27A_RABIT Large ribosomal subunit protein uL15 (Gene Name=RPL27A)