Structure of PDB 6qx2 Chain a

Receptor sequence
>6qx2a (length=481) Species: 1280 (Staphylococcus aureus) [Search protein sequence]
ERNITSEMRESFLDYAMSVIVARALPDVRDGLKPVHRRILYGLNEQGMTP
DKSYKKSARIVGDVMGKYHPHGDSSIYEAMVRMAQDFSYRYPLVDGQGNF
GSMDGDGAAAMRYTEARMTKITLELLRDINKDTIDFIDNYDGNEREPSVL
PARFPNLLANGASGIAVGMATNIPPHNLTELINGVLSLSKNPDISIAELM
EDIEGPDFPTAGLILGKSGIRRAYETGRGSIQMRSRAVIEERGGGRQRIV
VTEIPFQVNKARMIEKIAELVRDKKIDGITDLRDETSLRTGVRVVIDVRK
DANASVILNNLYKQTPLQTSFGVNMIALVNGRPKLINLKEALVHYLEHQK
TVVRRRTQYNLRKAKDRAHILEGLRIALDHIDEIISTIRESDTDKVAMES
LQQRFKLSEKQAQAILDMRLRRLTGLERDKIEAEYNELLNYISELETILA
DEEVLLQLVRDELTEIRDRFGDDRRTEIQLG
3D structure
PDB6qx2 Structure-guided design of antibacterials that allosterically inhibit DNA gyrase.
Chaina
Resolution3.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 5.6.2.2: DNA topoisomerase (ATP-hydrolyzing).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna a R33 K43 H46 H79 H81 G82 S85 R92 S173 I175 R272 S330 R23 K33 H36 H69 H71 G72 S75 R82 S163 I165 R262 S320
BS02 dna a I175 G178 M179 G332 I165 G168 M169 G322
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005524 ATP binding
Biological Process
GO:0006259 DNA metabolic process
GO:0006265 DNA topological change

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Molecular Function
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Biological Process
External links
PDB RCSB:6qx2, PDBe:6qx2, PDBj:6qx2
PDBsum6qx2
PubMed30962087
UniProtQ99XG5|GYRA_STAAN DNA gyrase subunit A (Gene Name=gyrA)

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