Structure of PDB 6m12 Chain a

Receptor sequence
>6m12a (length=681) Species: 9823 (Sus scrofa) [Search protein sequence]
SLEEMLTQAVQEADIEQVRQLLERGADANFQEEEWGWSPLHSAVQMDSED
LVALLLKHGADPCLRKRNGATPFIIAGITGNVRLLQLLLPNVEDVNECDV
NGFTAFMEAAVYGRVEALRFLYENGADVNMHRKTKQDQERIRKGGATALM
DAAEKGHVGVVTILLHAMKAEVDARDNMGRNALVYALLNPDDGKAKAITR
LLLDHGADVNVRGEGSKTPLILAVERKNLDLVQMLLEQEQIEVNDTDREG
KTALLLAVELRLEEIAKLLCHRGASTNCGDLVAIARRNYDSDLVKFLRLH
KPPAENWKPQSSRWGEALKHLHRIWRPMIGKLKIFIDEEYKIADTAEGGI
YLGLYEDQEVAVKRFSEGSTRGQQEVSCLQSSRANDNVVTFYGSESDGSC
LHVCLALCEYTLQEHLANHRGDAVPNEEDESARNILSSLFKAIGELHRSG
YSHQDLQPQNILIDSKNGTFLADFDKSIKWAEDPQKIKRDLEALGLLVLY
VVKKGDISFETLKNQSFEEVIQGSPDEETRDLIHHLFHPGDNVEDRLSSL
LAHPFFWSWESRYRTLRDVGNESDIKTRNQNSRILQLLQPSELSTSFAQW
TTKIDSFVMEEMNAYLYQDTLGDLLKFIRNLGEHINEQKNKKMKSIIGEP
SQYFQEKFPDLVMYVYTKLQNTEYMKHFPKT
3D structure
PDB6m12 Sunitinib inhibits RNase L by destabilizing its active dimer conformation.
Chaina
Resolution2.4 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 J60 a I369 A370 A388 L432 L489 A499 D500 I342 A343 A361 L405 L462 A472 D473
BS02 25L a W56 W58 Q66 K87 N89 N122 F124 E129 Y133 R153 W35 W37 Q45 K66 N68 N101 F103 E108 Y112 R132
BS03 25L a R307 Y310 R353 F362 R286 Y289 R326 F335
Gene Ontology
Molecular Function
GO:0004540 RNA nuclease activity
GO:0004672 protein kinase activity
GO:0005524 ATP binding
GO:0046872 metal ion binding
Biological Process
GO:0006397 mRNA processing
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6m12, PDBe:6m12, PDBj:6m12
PDBsum6m12
PubMed32830849
UniProtA5H025

[Back to BioLiP]