Structure of PDB 6giq Chain a

Receptor sequence

>6giqa (length=522) Species: 580240 (Saccharomyces cerevisiae W303)

DIAVLYFMLAIFSGMAGTAMSLIIRLELAAPGSQYLHGNSQLFNVLVVGH
AVLMIFFLVMPALIGGFGNYLLPLMIGATDTAFPRINNIAFWVLPMGLVC
LVTSTLVESGAGTGWTVYPPLSSIQAHSGPSVDLAIFALHLTSISSLLGA
INFIVTTLNMRTNGMTMHKLPLFVWSIFITAFLLLLSLPVLSAGITMLLL
DRNFNTSFFEVSGGGDPILYEHLFWFFGHPEVYILIIPGFGIISHVVSTY
SKKPVFGEISMVYAMASIGLLGFLVWSHHMYIVGLDADTRAYFTSATMII
AIPTGIKIFSWLATIHGGSIRLATPMLYAIAFLFLFTMGGLTGVALANAS
LDVAFHDTYYVVGHFHYVLSMGAIFSLFAGYYYWSPQILGLNYNEKLAQI
QFWLIFIGANVIFFPMHFLGINGMPRRIPDYPDAFAGWNYVASIGSFIAT
LSLFLFIYILYDQLVNGLNNKVNNKSVIYNKAPDFVESNTIFNLNTVKSS
SIEFLLTSPPAVHSFNTPAVQS

3D structure

• PDB: 6giq Cryo-EM structure of the yeast respiratory supercomplex.
• Chain: a
• Resolution: 3.23 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): H62 D92 W127 S157 S158 H241 E243 Y245 S256 H290 H291 T316 K319 R438
• Catalytic site (residue number reindexed from 1): H50 D80 W115 S145 S146 H229 E231 Y233 S244 H278 H279 T304 K307 R426
• Enzyme Commision number: 7.1.1.9: cytochrome-c oxidase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	a	L118 E120	L106 E108
BS02	CU	a	H241 H290 H291	H229 H278 H279
BS03	HEA	a	G26 T30 S33 I36 R37 H62 M66 I67 W127 Y371 V374 F377 H378 L389 F390 F425 R438 R439 A461 L465 F468	G14 T18 S21 I24 R25 H50 M54 I55 W115 Y359 V362 F365 H366 L377 F378 F413 R426 R427 A449 L453 F456
BS04	HEA	a	W127 W237 V244 I248 H290 H291 A313 G317 G352 G355 V356 L358 A359 D364 H368 V373 H376 F377 V380 L381 R438	W115 W225 V232 I236 H278 H279 A301 G305 G340 G343 V344 L346 A347 D352 H356 V361 H364 F365 V368 L369 R426

Gene Ontology

Molecular Function

• GO:0004129 cytochrome-c oxidase activity
• GO:0005515 protein binding
• GO:0020037 heme binding
• GO:0046872 metal ion binding

Biological Process

• GO:0006119 oxidative phosphorylation
• GO:0006123 mitochondrial electron transport, cytochrome c to oxygen
• GO:0009060 aerobic respiration
• GO:0015990 electron transport coupled proton transport
• GO:0045333 cellular respiration

Cellular Component

• GO:0005739 mitochondrion
• GO:0005743 mitochondrial inner membrane
• GO:0016020 membrane
• GO:0031966 mitochondrial membrane
• GO:0045277 respiratory chain complex IV

External links

• PDB: RCSB:6giq, PDBe:6giq, PDBj:6giq
• PDBsum: 6giq
• PubMed: 30598556
• UniProt: P00401|COX1_YEAST Cytochrome c oxidase subunit 1 (Gene Name=COX1)