Structure of PDB 6exn Chain a

Receptor sequence
>6exna (length=171) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence]
NRPERIQEAIAQDKTSVIIDPSQIGSTEGKPLLSMKCNLYIHEILSRWKA
SLEAYHPELFLDTKKALFPLLLQLRRNQLAPDLLISLATVLYHLQQPKEI
NLAVQSYMKLSIGNVAWPIGVTSVGIHARSAHSKIQGGRNAANIMIDERT
RLWITSIKRLITFEEWYTSNH
3D structure
PDB6exn Postcatalytic spliceosome structure reveals mechanism of 3'-splice site selection.
Chaina
Resolution3.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna a I202 R205 I126 R129
Gene Ontology
Molecular Function
GO:0000386 second spliceosomal transesterification activity
Biological Process
GO:0000350 generation of catalytic spliceosome for second transesterification step
GO:0000398 mRNA splicing, via spliceosome
GO:0006397 mRNA processing
GO:0008380 RNA splicing
GO:0071028 nuclear mRNA surveillance
Cellular Component
GO:0005634 nucleus
GO:0005681 spliceosomal complex
GO:0005682 U5 snRNP
GO:0046540 U4/U6 x U5 tri-snRNP complex
GO:0071021 U2-type post-spliceosomal complex

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Cellular Component
External links
PDB RCSB:6exn, PDBe:6exn, PDBj:6exn
PDBsum6exn
PubMed29146871
UniProtP33411|PRP18_YEAST Pre-mRNA-splicing factor 18 (Gene Name=PRP18)

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