Structure of PDB 4um3 Chain a

Receptor sequence
>4um3a (length=197) Species: 6523 (Lymnaea stagnalis) [Search protein sequence]
LDRADILYNIRQTSRPDVIPTDRPVAVSVSLKFINILEVNEITNEVDVVF
WQQTTWSDRTLAWNSSHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQL
AHVVSDGEVQYTPSIRQRFSCDVSGVDTESGATCRIKIGSWTHHSREISV
DPTSEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEVSLNFRKKG
3D structure
PDB4um3 Achbp Engineered to Mimic the Alpha4-Alpha4 Binding Pocket in Alpha4Beta2 Nicotinic Acetylcholine Receptors Reveals Interface Specific Interactions Important for Binding and Activity
Chaina
Resolution2.703 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 09R a W53 H104 Q112 T114 W51 H102 Q110 T112 BindingDB: Ki=1.3nM
BS02 09R a Y89 W143 Y185 C187 Y192 Y87 W141 Y177 C179 Y184 BindingDB: Ki=1.3nM
Gene Ontology
Molecular Function
GO:0004888 transmembrane signaling receptor activity
GO:0005216 monoatomic ion channel activity
GO:0005230 extracellular ligand-gated monoatomic ion channel activity
Biological Process
GO:0006811 monoatomic ion transport
GO:0034220 monoatomic ion transmembrane transport
Cellular Component
GO:0016020 membrane

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Molecular Function
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Cellular Component
External links
PDB RCSB:4um3, PDBe:4um3, PDBj:4um3
PDBsum4um3
PubMed26180047
UniProtP58154|ACHP_LYMST Acetylcholine-binding protein

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