Structure of PDB 4q1s Chain a

Receptor sequence
>4q1sa (length=233) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence]
TQQPIVTGTSVISMKYDNGVIIAADNLGSYGSLLRFNGVERLIPVGDNTV
VGISGDISDMQHIERLLKDLVTENAYDNPLADAEEALEPSYIFEYLATVM
YQRRSKMNPLWNAIIVAGVQSNGDQFLRYVNLLGVTYSSPTLATGFGAHM
ANPLLRKVVDRESDIPKTTVQVAEEAIVNAMRVLYYRDARSSRNFSLAII
DKNTGLTFKKNLQVENMKWDFAKDIKGYGTQKI
3D structure
PDB4q1s Interactions of the natural product kendomycin and the 20S proteasome.
Chaina
Resolution2.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.25.1: proteasome endopeptidase complex.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 2YD a L154 K157 N179 L154 K157 N179 PDBbind-CN: -logKd/Ki=4.17,IC50=67.9uM
Gene Ontology
Molecular Function
GO:0003674 molecular_function
GO:0005515 protein binding
Biological Process
GO:0010499 proteasomal ubiquitin-independent protein catabolic process
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043248 proteasome assembly
GO:0051603 proteolysis involved in protein catabolic process
Cellular Component
GO:0000502 proteasome complex
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005839 proteasome core complex
GO:0019774 proteasome core complex, beta-subunit complex
GO:0034515 proteasome storage granule

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4q1s, PDBe:4q1s, PDBj:4q1s
PDBsum4q1s
PubMed25038530
UniProtP30657|PSB7_YEAST Proteasome subunit beta type-7 (Gene Name=PRE4)

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