Structure of PDB 8shl Chain Z

Receptor sequence
>8shlZ (length=525) Species: 9606 (Homo sapiens) [Search protein sequence]
AAVKTLNPKAEVARAQAALAVNISAARGLQDVLRTNLGPKGTMKMLVSGA
GDIKLTKDGNVLLHEMQIQHPTASLIAKVATAQDDITGDGTTSNVLIIGE
LLKQADLYISEGLHPRIITEGFEAAKEKALQFLEEVKVSREMDRETLIDV
ARTSLRTKVHAELADVLTEAVVDSILAIKKQDEPIDLFMIEIMEMKHKSE
TDTSLIRGLVLDHGARHPDMKKRVEDAYILTCNVSLEYEKTEVNSGFFYK
SAEEREKLVKAERKFIEDRVKKIIELKRKVCGDSDKGFVVINQKGIDPFS
LDALSKEGIVALRRAKRRNMERLTLACGGVALNSFDDLSPDCLGHAGLVY
EYTLGEEKFTFIEKCNNPRSVTLLIKGPNKHTLTQIKDAVRDGLRAVKNA
IDDGCVVPGAGAVEVAMAEALIKHKPSVKGRAQLGVQAFADALLIIPKVL
AQNSGFDLQETLVKIQAEHSESGQLVGVDLNTGEPMVAAEVGVWDNYCVK
KQLLHSCTVIATNILLVDEIMRAGM
3D structure
PDB8shl Visualizing the chaperone-mediated folding trajectory of the G protein beta 5 beta-propeller structure
ChainZ
Resolution3.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP Z L38 D90 G91 T92 T93 T158 K159 G410 A411 L451 L481 L37 D89 G90 T91 T92 T157 K158 G409 A410 L450 L480
BS02 MG Z D90 K159 D89 K158
BS03 AF3 Z D59 G60 D90 G91 T92 T93 K159 D393 D58 G59 D89 G90 T91 T92 K158 D392
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
GO:0044183 protein folding chaperone
GO:0051082 unfolded protein binding
GO:0071987 WD40-repeat domain binding
GO:0140662 ATP-dependent protein folding chaperone
Biological Process
GO:0006457 protein folding
GO:0032212 positive regulation of telomere maintenance via telomerase
GO:0050821 protein stabilization
GO:0051086 chaperone mediated protein folding independent of cofactor
GO:0061077 chaperone-mediated protein folding
GO:1904851 positive regulation of establishment of protein localization to telomere
GO:1904871 positive regulation of protein localization to Cajal body
GO:1904874 positive regulation of telomerase RNA localization to Cajal body
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005832 chaperonin-containing T-complex
GO:0005874 microtubule
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8shl, PDBe:8shl, PDBj:8shl
PDBsum8shl
PubMed37852256
UniProtP40227|TCPZ_HUMAN T-complex protein 1 subunit zeta (Gene Name=CCT6A)

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