Structure of PDB 7mxw Chain Z

Receptor sequence
>7mxwZ (length=350) Species: 9606 (Homo sapiens) [Search protein sequence]
GIQGLLQFIKEASEPIHVRKYKGQVVAVDTYCWLHKGAIACAEKLAKGEP
TDRYVGFCMKFVNMLLSHGIKPILVFDGCTLPSKKEVERSRRERRQANLL
KGKQLLREGKVSEARECFTRSINITHAMAHKVIKAARSQGVDCLVAPYEA
DAQLAYLNKAGIVQAIITEDSDLLAFGCKKVILKMDQFGNGLEIDQARLG
MCRQLGDVFTEEKFRYMCILSGCDYLSSLRGIGLAKACKVLRLANNPDIV
KVIKKIGHYLKMNITVPEDYINGFIRANNTFLYQLVFDPIKRKLIPLNAY
EDDVDPETLSYAGQYVDDSIALQIALGNKDINTFEQIDDYNPDTAENLYF
3D structure
PDB7mxw Structures of reaction intermediates reveal transient Mg2+-binding events that dynamically coordinate Human Exonuclease I activities
ChainZ
Resolution2.836 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 3.1.-.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna Z Q4 K37 I40 F58 T120 R121 G232 G234 A236 K237 Q3 K36 I39 F57 T119 R120 G231 G233 A235 K236
BS02 dna Z H36 K85 R92 R96 I125 E150 D152 D171 K185 D225 H35 K84 R91 R95 I124 E149 D151 D170 K184 D224
BS03 MG Z D152 D171 D173 D151 D170 D172
BS04 MG Z G2 D173 D225 G1 D172 D224
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003824 catalytic activity
GO:0004518 nuclease activity
GO:0016788 hydrolase activity, acting on ester bonds
GO:0035312 5'-3' DNA exonuclease activity
GO:0046872 metal ion binding

View graph for
Molecular Function
External links
PDB RCSB:7mxw, PDBe:7mxw, PDBj:7mxw
PDBsum7mxw
PubMed
UniProtQ9UQ84|EXO1_HUMAN Exonuclease 1 (Gene Name=EXO1)

[Back to BioLiP]