Structure of PDB 7lxu Chain Z

Receptor sequence
>7lxuZ (length=209) Species: 36329 (Plasmodium falciparum 3D7) [Search protein sequence]
TTTLAFKFKDGIIVAVDSRASMGSFISSQNVEKIIEINKNILGTMAGGAA
DCLYWEKYLGKIIKIYELRNNEKISVRAASTILSNILYQYKGYGLCCGII
LSGYDHTGFNMFYVDDSGKKVEGNLFSCGSGSTYAYSILDSAYDYNLNLD
QAVELARNAIYHATFRDGGSGGKVRVFHIHKNGYDKIIEGEDVFDLHYHY
TNPEQKDQY
3D structure
PDB7lxu Design of proteasome inhibitors with oral efficacy in vivo against Plasmodium falciparum and selectivity over the human proteasome.
ChainZ
Resolution3.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.25.1: proteasome endopeptidase complex.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 YHD Z T1 A20 S21 V31 E32 M45 G47 A49 L53 T1 A20 S21 V31 E32 M45 G47 A49 L53
Gene Ontology
Molecular Function
GO:0004298 threonine-type endopeptidase activity
Biological Process
GO:0051603 proteolysis involved in protein catabolic process
Cellular Component
GO:0005839 proteasome core complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7lxu, PDBe:7lxu, PDBj:7lxu
PDBsum7lxu
PubMed34548400
UniProtQ8IJT1

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