Structure of PDB 5v09 Chain Z

Receptor sequence
>5v09Z (length=347) Species: 9606 (Homo sapiens) [Search protein sequence]
GIQGLLQFIKEASEPIHVRKYKGQVVAVDTYCWLHKGAIACAEKLAKGEP
TDRYVGFCMKFVNMLLSHGIKPILVFDGCTLPSKKEVERSRRERRQANLL
KGKQLLREGKVSEARECFTRSINITHAMAHKVIKAARSQGVDCLVAPYEA
DAQLAYLNKAGIVQAIITEDSDLLAFGCKKVILKMDQFGNGLEIDQARLG
MCRQLGDVFTEEKFRYMCILSGCAYLSSLRGIGLAKACKVLRLANNPDIV
KVIKKIGHYLKMNITVPEDYINGFIRANNTFLYQLVFDPIKRKLIPLNAY
EDDVDPETLSYAGQYVDDSIALQIALGNKDINTFEQIDDYNPDTLYF
3D structure
PDB5v09 Interplay of catalysis, fidelity, threading, and processivity in the exo- and endonucleolytic reactions of human exonuclease I.
ChainZ
Resolution2.75 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.-.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna Z Q4 K37 I40 A41 R54 F58 R121 R231 G232 I233 G234 A236 K237 Q3 K36 I39 A40 R53 F57 R120 R230 G231 I232 G233 A235 K236
BS02 dna Z H36 K85 R92 D152 D171 S172 K185 H35 K84 R91 D151 D170 S171 K184
BS03 MN Z D152 D171 D173 D151 D170 D172
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003824 catalytic activity
GO:0004518 nuclease activity
GO:0016788 hydrolase activity, acting on ester bonds
GO:0035312 5'-3' DNA exonuclease activity
GO:0046872 metal ion binding

View graph for
Molecular Function
External links
PDB RCSB:5v09, PDBe:5v09, PDBj:5v09
PDBsum5v09
PubMed28533382
UniProtQ9UQ84|EXO1_HUMAN Exonuclease 1 (Gene Name=EXO1)

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