Structure of PDB 5v08 Chain Z

Receptor sequence
>5v08Z (length=343) Species: 9606 (Homo sapiens) [Search protein sequence]
IQGLLQFIKEASEPIHVRKYKGQVVAVDTYCWLHKGAIACAEKLAKGEPT
DRYVGFCMKFVNMLLSHGIKPILVFDGCTLPSKKEVERSRRERRQANLLK
GKQLLREGKVSEARECFTRSINITHAMAHKVIKAARSQGVDCLVAPYEAD
AQLAYLNKAGIVQAIITEDSALLAFGCKKVILKMDQFGNGLEIDQARLGM
CRQLGDVFTEEKFRYMCILSGCDYLSSLRGIGLAKACKVLRLANNPDIVK
VIKKIGHYLKMNITVPEDYINGFIRANNTFLYQLVFDPIKRKLIPLNAYE
DDVDPETLSYAGQYVDDSIALQIALGNKDINTFEQIDDYNPDT
3D structure
PDB5v08 Interplay of catalysis, fidelity, threading, and processivity in the exo- and endonucleolytic reactions of human exonuclease I.
ChainZ
Resolution2.812 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.-.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna Z I40 F58 R121 R231 G232 I233 G234 A236 K237 I38 F56 R119 R229 G230 I231 G232 A234 K235
BS02 dna Z Q8 H36 R92 D152 D171 K185 Q6 H34 R90 D150 D169 K183
BS03 MG Z D152 D171 D150 D169
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003824 catalytic activity
GO:0004518 nuclease activity
GO:0016788 hydrolase activity, acting on ester bonds
GO:0035312 5'-3' DNA exonuclease activity
GO:0046872 metal ion binding

View graph for
Molecular Function
External links
PDB RCSB:5v08, PDBe:5v08, PDBj:5v08
PDBsum5v08
PubMed28533382
UniProtQ9UQ84|EXO1_HUMAN Exonuclease 1 (Gene Name=EXO1)

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