Structure of PDB 2wva Chain Z

Receptor sequence
>2wvaZ (length=565) Species: 542 (Zymomonas mobilis) [Search protein sequence]
SYTVGTYLAERLVQIGLKHHFAVAGDYNLVLLDNLLLNKNMEQVYCCNEL
NCGFSAEGYARAKGAAAAVVTYSVGALSAFDAIGGAYAENLPVILISGAP
NNNDHAAGHVLHHALGKTDYHYQLEMAKNITAAAEAIYTPEEAPAKIDHV
IKTALREKKPVYLEIACNIASMPCAAPGPASALFNDEASDEASLNAAVEE
TLKFIANRDKVAVLVGSKLRAAGAEEAAVKFADALGGAVATMAAAKSFFP
EENPHYIGTSWGEVSYPGVEKTMKEADAVIALAPVFNDYSTTGWTDIPDP
KKLVLAEPRSVVVNGIRFPSVHLKDYLTRLAQKVSKKTGALDFFKSLNAG
ELKKAAPADPSAPLVNAEIARQVEALLTPNTTVIAETGDSWFNAQRMKLP
NGARVEYEMQWGHIGWSVPAAFGYAVGAPERRNILMVGDGSFQLTAQEVA
QMVRLKLPVIIFLINNYGYTIEVMIHDGPYNNIKNWDYAGLMEVFNGNGG
YDSGAGKGLKAKTGGELAEAIKVALANTDGPTLIECFIGREDCTEELVKW
GKRVAAANSRKPVNK
3D structure
PDB2wva Structural Insights Into the Pre-Reaction State of Pyruvate Decarboxylase from Zymomonas Mobilis
ChainZ
Resolution2.2 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) L116 G117 T388 G413 D440 N467 G469 I472 E473
Catalytic site (residue number reindexed from 1) L115 G116 T387 G412 D439 N466 G468 I471 E472
Enzyme Commision number 4.1.1.1: pyruvate decarboxylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 TPU Z A25 E50 V75 H114 A24 E49 V74 H113 PDBbind-CN: -logKd/Ki=10.70,Kd=20pM
BS02 PYR Z Y290 I472 E473 Y289 I471 E472
BS03 MG Z D440 N467 G469 D439 N466 G468
BS04 TPU Z G389 D390 G413 H414 I415 G439 G441 S442 G469 Y470 T471 I472 E473 G388 D389 G412 H413 I414 G438 G440 S441 G468 Y469 T470 I471 E472 PDBbind-CN: -logKd/Ki=10.70,Kd=20pM
BS05 PYR Z G26 D27 H114 G25 D26 H113
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0003824 catalytic activity
GO:0004737 pyruvate decarboxylase activity
GO:0016831 carboxy-lyase activity
GO:0030976 thiamine pyrophosphate binding
GO:0046872 metal ion binding
Biological Process
GO:0000949 aromatic amino acid family catabolic process to alcohol via Ehrlich pathway
GO:0019752 carboxylic acid metabolic process
Cellular Component
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2wva, PDBe:2wva, PDBj:2wva
PDBsum2wva
PubMed20099870
UniProtP06672|PDC_ZYMMO Pyruvate decarboxylase (Gene Name=pdc)

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