Structure of PDB 1sgf Chain Z

Receptor sequence
>1sgfZ (length=232) Species: 10090 (Mus musculus) [Search protein sequence]
IVGGFKCEKNSQPWHVAVYRYTQYLCGGVLLDPNWVLTAAHCYDDNYKVW
LGKNNLFKDEPSAQHRFVSKAIPHPGFNMSLMFLEYDYSNDLMLLRLSKP
ADITDTVKPITLPTEEPKLGSTCLASGWGSITPTKFQFTDDLYCVNLKLL
PNEDCAKAHIEKVTDAMLCAGEMDGGKDTCKGDSGGPLICDGVLQGITSW
GHTPCGEPDMPGVYTKLNKFTSWIKDTMAKNP
3D structure
PDB1sgf Structure of mouse 7S NGF: a complex of nerve growth factor with four binding proteins.
ChainZ
Resolution3.15 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) G193 S195 G196
Catalytic site (residue number reindexed from 1) G182 S184 G185
Enzyme Commision number 3.4.21.35: tissue kallikrein.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN Z H217 E222 H202 E207
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0008083 growth factor activity
GO:0008236 serine-type peptidase activity
GO:0046872 metal ion binding
Biological Process
GO:0006508 proteolysis
GO:0007165 signal transduction

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:1sgf, PDBe:1sgf, PDBj:1sgf
PDBsum1sgf
PubMed9351801
UniProtP00756|K1KB3_MOUSE Kallikrein 1-related peptidase b3 (Gene Name=Klk1b3)

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