Structure of PDB 8y6o Chain Y

Receptor sequence
>8y6oY (length=229) Species: 9606 (Homo sapiens) [Search protein sequence]
MEGEPPPVEERRRLQEELNEFVESGCRTLEEVTASLGWDLDSLDPGAEDE
VVICPYDSNHHMPKSSLAKHMASCRLRKMGYTKEEEDEMYNPEFFYENVK
IPSITLNKDSQFQIIKQARTAVGKDSDCYNQRIYSSLPVEVPLNHKRFVC
DLTQADRLALYDFVVEETKKKRSDSQIIEEVRDYKRRRQSYRAKNVHITK
KSYTEVIRDVINVHMEELSNHWQEEQEKA
3D structure
PDB8y6o Structural basis of U12-type intron engagement by the fully assembled human minor spliceosome
ChainY
Resolution3.38 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna Y K219 R220 R222 Y225 K185 R186 R188 Y191
BS02 rna Y W38 L43 N63 H64 S70 R221 Y225 R226 N229 V230 K234 W38 L43 N59 H60 S66 R187 Y191 R192 N195 V196 K200
BS03 ZN Y C58 H64 H74 C78 C54 H60 H70 C74
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0046872 metal ion binding
Biological Process
GO:0006397 mRNA processing
GO:0008380 RNA splicing
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005681 spliceosomal complex
GO:0005689 U12-type spliceosomal complex
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8y6o, PDBe:8y6o, PDBj:8y6o
PDBsum8y6o
PubMed38484052
UniProtQ6IEG0|SNR48_HUMAN U11/U12 small nuclear ribonucleoprotein 48 kDa protein (Gene Name=SNRNP48)

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