Structure of PDB 8rch Chain Y

Receptor sequence

>8rchY (length=1044) Species: 9606 (Homo sapiens)

EADLTDWNLPLAFMKKRHCEKIEGSKSLAQSWRMKDRMKTVSVALVLCLN
VGVDPPDVVKTTPCARLECWIDPLSMGPQKALETIGANLQKQYENWQPRA
RYKQSLDPTVDEVKKLCTSLRRNAKEERVLFHYNGHGVPRPTVNGEVWVF
NKNYTQYIPLSIYDLQTWMGSPSIFVYDCSNAGLIVKSFKQFALQREQEL
EVSMKNCIQLAACEATELLPMIPDLPADLFTSCLTTPIKIALRWFCMQKC
VSLVPGVTLDLIEKIPGRLNDRRTPLGELNWIFTAITDTIAWNVLPRDLF
QKLFRQDLLVASLFRNFLLAERIMRSYNCTPVSSPRLPPTYMHAMWQAWD
LAVDICLSQLPTIIEEGTAFRHSPFFAEQLTAFQVWLTMGVENRNPPEQL
PIVLQVLLSQVHRLRALDLLGRFLDLGPWAVSLALSVGIFPYVLKLLQSS
ARELRPLLVFIWAKILAVDSSCQADLVKDNGHKYFLSVLADPYMPAEHRT
MTAFILAVIVNSYHTGQEACLQGNLIAICLEQLNDPHPLLRQWVAICLGR
IWQNFDSARWCGVRDSAHEKLYSLLSDPIPEVRCAAVFALGTFVGNSAER
TDHSTTIDHNVAMMLAQLVSDGSPMVRKELVVALSHLVVQYESNFCTVAL
QFISVYTQIWRVLLHLAADPYPEVSDVAMKVLNSIAYKGFCDWSARYFAQ
PVMKIPEEHDLESQIRKEREWRFLRNSRVRRQAQQVIQKGITRLDDQIFL
NRNPGVPSVVKFHPFTPCIAVADKDSICFWDWEKGEKLDYFHNGNPRYTR
VTAMEYLNGQDCSLLLTATDDGAIRVWKNFADLEKNPEMVTAWQGLSAGM
VVDWEQETGLLMSSGDVRIVRIWDTDREMKVQDIPTGADSCVTSLSCDSH
RSLIVAGLGDGSIRVYDRRMALSECRVMTYREHTAWVVKASLQKRPDGHI
VSVSVNGDVRIFDPRMPESVNVLQIVKGLTALDIHPQADLIACGSVNQFT
AIYNSSGELINNIKYAISCLAFHPHWPHLAVGSNDYYISVYSVE

3D structure

• PDB: 8rch cryoEM structure of mTORC1 with the cancer-associated 1455-EWED-1458 duplication variant, overall refinement
• Chain: Y
• Resolution: 4.0 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	Y	R338 L441 R446 Y475 K478 L479 S482	R305 L408 R413 Y442 K445 L446 S449

External links

• PDB: RCSB:8rch, PDBe:8rch, PDBj:8rch
• PDBsum: 8rch
• UniProt: Q8N122|RPTOR_HUMAN Regulatory-associated protein of mTOR (Gene Name=RPTOR)