Structure of PDB 6om0 Chain Y

Receptor sequence

>6om0Y (length=117) Species: 9606 (Homo sapiens)

KIRTSPTFRRPKTLRLRRQPKYPRKSAPRRNKLDHYAIIKFPLTTESAMK
KIEDNNTLVFIVDVKANKHQIKQAVKKLYDIDVAKVNTLIRPDGEKKAYV
RLAPDYDALDVANKIGI

3D structure

• PDB: 6om0 Structural basis for selective stalling of human ribosome nascent chain complexes by a drug-like molecule.
• Chain: Y
• Resolution: 3.1 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	Y	P49 T51 L52 R55 K63 R67 K70 K103 Q108	P11 T13 L14 R17 K25 R29 K32 K65 Q70
BS02	rna	Y	P44 F46 R47 R48 P49 K50 T51 R53 R56 Q57 K59 Y60 T83 S85 K89 N93 N105 K106 H107 K123 N125 T126 L127 I128 P130 K134 K135 Y137 R139	P6 F8 R9 R10 P11 K12 T13 R15 R18 Q19 K21 Y22 T45 S47 K51 N55 N67 K68 H69 K85 N87 T88 L89 I90 P92 K96 K97 Y99 R101

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome
• GO:0019843 rRNA binding

Biological Process

• GO:0006412 translation

Cellular Component

• GO:0005840 ribosome

External links

• PDB: RCSB:6om0, PDBe:6om0, PDBj:6om0
• PDBsum: 6om0
• PubMed: 31160784
• UniProt: P62750|RL23A_HUMAN Large ribosomal subunit protein uL23 (Gene Name=RPL23A)