Structure of PDB 6ny2 Chain Y

Receptor sequence

>6ny2Y (length=915) Species: 2026735 (Deltaproteobacteria bacterium) [Search protein sequence]

EKRINKIRKKLSADNATKPVSRSGPMKTLLVRVMTDDLKKRLEKRRKKPE
VMPQVISNNAANNLRMLLDDYTKMKEAILQVYWQEFKDDHVGLMCKFAQP
ASAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAGKFGQRALDFYSIHVTKESTHPVKPLAQIAGNRYASGPVGK
ALSDACMGTIASFLSKYQDIIIEHQKVVKGNQKRLESLRELAGKENLEYP
SVTLPPQPHTKEGVDAYNEVIARVRMWVNLNLWQKLKLSRDDAKPLLRLK
GFPSFPVVERRENEVDWWNTINEVKKLIDAKRDMGRVFWSGVTAEKRNTI
LEGYNYLPNENDHKKRENPKKPAKRQFGDLLLYLEKKYWGKVFDEAWERI
DKKIAGLTSHIEREEARNAEDAQSKAVLTDWLRAKASFVLERLKEMDEKE
FYACEIQLQKWYGDLRGNPFAVEAENRVVDISGFSIGSDGHSIQYRNLLA
WKYLENGKREFYLLMNYGKKGRIRFTDGTDIKKSGKWQGLLYGGGKAKVI
DLTFDPDDEQLIILPLAFGTRQGREFIWNDLLSLETGLIKLANGRVIEKT
IYNKKIGRDEPALFVALTFERREVVDPSNIKPVNLIGVARGENIPAVIAL
TDPEGCPLRIGEGYKEKQRAIQAAKEVEQRRAGGYSRKFASKSRNLADDM
VRNSARDLFYHAVTHDAVLVFANLSRGFGRQGKRTFMTERQYTKMEDWLT
AKLAYEGLTSKTYLSKTLAQYTSKTCSNCGAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAARFSHRP
VQEQFVCLDCGHEVHAAEQAALNIARSWLFLNSNSTEFKSYKSGKQPFVG
AWQAFYKRRLKEVWK

3D structure

PDB

6ny2 CasX enzymes comprise a distinct family of RNA-guided genome editors.

Chain

Resolution

3.2 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	dna	Y	M27 K187 Q190 R191 K226 G234 S238 S241 K242 R301 N305 R316 R324 N339 N385 G496 A504 V505 G516 F517 S518 Y528 G577 A625 R734 A737 S740 R741 R773 M784 T790 K791	M26 K161 Q164 R165 K200 G208 S212 S215 K216 R275 N279 R290 R298 N313 N359 G463 A471 V472 G483 F484 S485 Y495 G544 A592 R687 A690 S693 R694 R726 M737 T743 K744
BS02	dna	Y	R23 X134 X135 Y196 T201 K202 S221 K552 K553 G554 E675 N676 F775 R777 Q817 Y818 T819 S820 K821 X876 Q920 Y959	R22 X130 X131 Y170 T175 K176 S195 K519 K520 G521 E642 N643 F728 R730 Q770 Y771 T772 S773 K774 X808 Q852 Y891
BS03	rna	Y	R4 I5 N6 K10 M27 K28 T29 L31 R33 R42 R46 R47 P54 L306 Q310 K326 G327 P329 S330 P332 R336 Y380 N398 K401 K404 Q406 Y413 E431 R432 K435 K436 L440 H443 E447 Q456 S457 R466 Y485 E488 Q492 Y495 R499 N509 K541 R542 E543 L599 A600 F601 G602 T603 R604 Q605 R607 W611 Q726 R727 R728 K735 R749 R753 G779 K780 F783 M784 W795	R3 I4 N5 K9 M26 K27 T28 L30 R32 R41 R45 R46 P53 L280 Q284 K300 G301 P303 S304 P306 R310 Y354 N368 K371 K374 Q376 Y383 E398 R399 K402 K403 L407 H410 E414 Q423 S424 R433 Y452 E455 Q459 Y462 R466 N476 K508 R509 E510 L566 A567 F568 G569 T570 R571 Q572 R574 W578 Q679 R680 R681 K688 R702 R706 G732 K733 F736 M737 W748

External links

PDB	RCSB:6ny2, PDBe:6ny2, PDBj:6ny2
PDBsum	6ny2
PubMed	30718774
UniProt	A0A357BT59

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