Structure of PDB 5yzg Chain Y

Receptor sequence
>5yzgY (length=204) Species: 9606 (Homo sapiens) [Search protein sequence]
SERKVLNKYYPPDFDPSKIPKLKLPKDRQYVVRLMAPFNMRCKTCGEYIY
KGKKFNARKETVQNEVYLGLPIFRFYIKCTRCLAEITFKTDPENTDYTME
HGATRNFQAEKLLEEEEKRVQKEREDEELNNPMKVLENRTKDSKLEMEVL
ENLQELKDLNQRQAHVDFEAMLRQHRLSEEERRRQQQEEDEQETAALLEE
ARKR
3D structure
PDB5yzg Structure of a human catalytic step I spliceosome
ChainY
Resolution4.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna Y R34 M36 Y51 K54 K55 N57 K79 R33 M35 Y50 K53 K54 N56 K78
BS02 rna Y R4 V33 K60 R3 V32 K59
BS03 rna Y R4 K9 K22 K24 R3 K8 K21 K23
BS04 ZN Y C43 C46 C80 C83 C42 C45 C79 C82
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0046872 metal ion binding
Biological Process
GO:0000349 generation of catalytic spliceosome for first transesterification step
GO:0000398 mRNA splicing, via spliceosome
GO:0006397 mRNA processing
GO:0008380 RNA splicing
GO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005681 spliceosomal complex
GO:0071006 U2-type catalytic step 1 spliceosome

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Molecular Function
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Cellular Component
External links
PDB RCSB:5yzg, PDBe:5yzg, PDBj:5yzg
PDBsum5yzg
PubMed29301961
UniProtQ9BW85|YJU2_HUMAN Splicing factor YJU2 (Gene Name=YJU2)

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