Structure of PDB 5yj0 Chain Y

Receptor sequence
>5yj0Y (length=94) Species: 10090 (Mus musculus) [Search protein sequence]
GPTSLCCKQCQETEITTKNEIFSLSLHETLTVYKASNLNLIGRPSTVHSW
FPGYAWTIAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLP
3D structure
PDB5yj0 Structural basis of thalidomide enantiomer binding to cereblon
ChainY
Resolution1.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 EF2 Y H381 S382 W383 W389 W403 F405 H48 S49 W50 W56 W70 F72 MOAD: Kd=5.7uM
BS02 ZN Y C326 C329 C394 C397 C7 C10 C61 C64
External links
PDB RCSB:5yj0, PDBe:5yj0, PDBj:5yj0
PDBsum5yj0
PubMed29358579
UniProtQ8C7D2|CRBN_MOUSE Protein cereblon (Gene Name=Crbn)

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